ul_8----
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PPBD protein
Gene name SFN( Description: stratifin. )
Synonyms Epithelial cell marker protein 1; Stratifin; YWHAS
GO annotations GO_component: cytoplasm [PMID 10767298]; extracellular space [PMID 8515476]
GO_function:protein domain specific binding; protein kinase C inhibitor activity [PMID 8515476]
GO_process: cell proliferation [PMID 10767298]; negative regulation of protein kinase activity [PMID 8515476]; regulation of progression through cell cycle [PMID 10767298]; signal transduction [PMID 8515476]
RefSeq accession NP_006133
SwissProt accession P31947
Substrate protein
Gene name CDC25C
Synonyms Dual specificity phosphatase Cdc25C; EC 3.1.3.48
GO annotations GO_component: intracellular; nucleus
GO_function:hydrolase activity; protein tyrosine phosphatase activity [PMID 11078813]
GO_process: cell cycle; cell division; cell proliferation [PMID 11139144]; protein amino acid dephosphorylation; regulation of cyclin-dependent protein kinase activity [PMID 11139144]; regulation of mitosis [PMID 1828290]; traversing start control point of mitotic cell cycle [PMID 2195549]
RefSeq accession NP_001781
SwissProt accession P30307
GO Pathway:
GO:0007049     cell cycle
Sequence:(RefSeq accession:NP_001781; substrate region highlighted if known)
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MSTELFSSTR EEGSSGSGPS FRSNQRKMLN LLLERDTSFT VCPDVPRTPV GKFLGDSANL
SILSGGTPKC CLDLSNLSSG EITATQLTTS ADLDETGHLD SSGLQEVHLA GMNHDQHLMK
CSPAQLLCST PNGLDRGHRK RDAMCSSSAN KENDNGNLVD SEMKYLGSPI TTVPKLDKNP
NLGEDQAEEI SDELMEFSLK DQEAKVSRSG LYRSPSMPEN LNRPRLKQVE KFKDNTIPDK
VKKKYFSGQG KLRKGLCLKK TVSLCDITIT QMLEEDSNQG HLIGDFSKVC ALPTVSGKHQ
DLKYVNPETV AALLSGKFQG LIEKFYVIDC RYPYEYLGGH IQGALNLYSQ EELFNFFLKK
PIVPLDTQKR IIIVFHCEFS SERGPRMCRC LREEDRSLNQ YPALYYPELY ILKGGYRDFF
PEYMELCEPQ SYCPMHHQDH KTELLRCRSQ SKVQEGERQL REQIALLVKD MSP
Records:
Category Evidence Reference
A Mutagenesis Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H., Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis., [9278512]
End of Record Details