ul_815----
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PPBD protein
Gene name YWHAZ
Synonyms KCIP-1; Protein kinase C inhibitor protein 1
GO annotations GO_component:
GO_function:protein domain specific binding; transcription factor binding [PMID 16114898]
GO_process:
RefSeq accession NP_003397
SwissProt accession P63104
Substrate protein
Gene name FOXO3
Synonyms AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1
GO annotations GO_component: cytoplasm [PMID 10102273]; nucleus [PMID 10102273]
GO_function:sequence-specific DNA binding; transcription factor activity [PMID 14734530]
GO_process: apoptosis; induction of apoptosis [PMID 10102273]; positive regulation of erythrocyte differentiation [PMID 14734530]; positive regulation of transcription from RNA polymerase II promoter [PMID 14734530]; regulation of transcription, DNA-dependent; transcription; transcription from RNA polymerase II promoter [PMID 10102273]
RefSeq accession NP_001446
SwissProt accession O43524
GO Pathway:
GO:0005737     cytoplasm
Sequence:(RefSeq accession:NP_001446; substrate region highlighted if known)
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MAEAPASPAP LSPLEVELDP EFEPQSRPRS CTWPLQRPEL QASPAKPSGE TAADSMIPEE
EDDEDDEDGG GRAGSAMAIG GGGGSGTLGS GLLLEDSARV LAPGGQDPGS GPATAAGGLS
GGTQALLQPQ QPLPPPQPGA AGGSGQPRKC SSRRNAWGNL SYADLITRAI ESSPDKRLTL
SQIYEWMVRC VPYFKDKGDS NSSAGWKNSI RHNLSLHSRF MRVQNEGTGK SSWWIINPDG
GKSGKAPRRR AVSMDNSNKY TKSRGRAAKK KAALQTAPES ADDSPSQLSK WPGSPTSRSS
DELDAWTDFR SRTNSNASTV SGRLSPIMAS TELDEVQDDD APLSPMLYSS SASLSPSVSK
PCTVELPRLT DMAGTMNLND GLTENLMDDL LDNITLPPSQ PSPTGGLMQR SSSFPYTTKG
SGLGSPTSSF NSTVFGPSSL NSLRQSPMQT IQENKPATFS SMSHYGNQTL QDLLTSDSLS
HSDVMMTQSD PLMSQASTAV SAQNSRRNVM LRNDPMMSFA AQPNQGSLVN QNLLHHQHQT
QGALGGSRAL SNSVSNMGLS ESSSLGSAKH QQQSPVSQSM QTLSDSLSGS SLYSTSANLP
VMGHEKFPSD LDLDMFNGSL ECDMESIIRS ELMDADGLDF NFDSLISTQN VVGLNVGNFT
GAKQASSQSW VPG
Records:
Category Evidence Reference
A Mutagenesis Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME., Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor., [10102273]
End of Record Details