ul_8531----
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PPBD protein
Gene name PIN1( Description: protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1. )
Synonyms DOD; EC 5.2.1.8; PPIase Pin1; Rotamase Pin1; UBL5
GO annotations GO_component: nucleus [PMID 8606777]
GO_function:isomerase activity; peptidyl-prolyl cis-trans isomerase activity; protein binding [PMID 11470801]
GO_process: cell cycle; protein folding; regulation of mitosis [PMID 10391244]
RefSeq accession NP_006212
SwissProt accession Q13526
Substrate protein
Gene name MAPT
Synonyms Neurofibrillary tangle protein; PHF-tau; Paired helical filament-tau
GO annotations GO_component: axon [PMID 8642405]; cytoskeleton; cytosol [PMID 10747907]; growth cone [PMID 8642405]; microtubule associated complex [PMID 10747907]; plasma membrane [PMID 8522593]; tubulin [PMID 8642405]
GO_function:enzyme binding [PMID 9736630] [PMID 12888622]; lipoprotein binding [PMID 7972031]; microtubule binding [PMID 1918161]; SH3 domain binding [PMID 9763511]; structural constituent of cytoskeleton [PMID 2498079]
GO_process: generation of neurons [PMID 8522593]; microtubule cytoskeleton organization and biogenesis [PMID 1057175]; negative regulation of microtubule depolymerization; positive regulation of axon extension [PMID 1389180]; positive regulation of microtubule polymerization [PMID 1421571]
RefSeq accession NP_005901
SwissProt accession P10636
GO Pathway:
GO:0007088    
Sequence:(RefSeq accession:NP_005901; substrate region highlighted if known)
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MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG
SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG
HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK
TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK
SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHV
PGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI
THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV
DSPQLATLAD EVSASLAKQG L
Records:
Category Evidence Reference
A Mutagenesis Lu PJ, Wulf G, Zhou XZ, Davies P, Lu KP., The WW domain of dystrophin requires EF-hands region to interact with beta-dystroglycan., [10391244]
A Structure Smet C, Sambo AV, Wieruszeski JM, Leroy A, Landrieu I, Buée L, Lippens G., The peptidyl prolyl cis/trans-isomerase Pin1 recognizes the phospho-Thr212-Pro213 site on Tau., [14967043]
A Structure Smet C, Wieruszeski JM, Buée L, Landrieu I, Lippens G., Regulation of Pin1 peptidyl-prolyl cis/trans isomerase activity by its WW binding module on a multi-phosphorylated peptide of Tau protein., [16024016]
End of Record Details