ul_8595----
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PPBD protein
Gene name PIN1( Description: protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1. )
Synonyms DOD; EC 5.2.1.8; PPIase Pin1; Rotamase Pin1; UBL5
GO annotations GO_component: nucleus [PMID 8606777]
GO_function:isomerase activity; peptidyl-prolyl cis-trans isomerase activity; protein binding [PMID 11470801]
GO_process: cell cycle; protein folding; regulation of mitosis [PMID 10391244]
RefSeq accession NP_006212
SwissProt accession Q13526
Substrate protein
Gene name JUN( Description: jun oncogene. )
Synonyms AP1; Activator protein 1; Proto-oncogene c-jun; V-jun avian sarcoma virus 17 oncogene homolog; c-Jun; p39
GO annotations GO_component: nuclear chromosome [PMID 10918580]; nucleus
GO_function:protein dimerization activity; RNA polymerase II transcription factor activity [PMID 9443941]; sequence-specific DNA binding; transcription factor activity [PMID 2825349] [PMID 10973489]
GO_process: regulation of transcription, DNA-dependent; transcription
RefSeq accession NP_002219
SwissProt accession P05412
Sequence:(RefSeq accession:NP_002219; substrate region highlighted if known)
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MTAKMETTFY DDALNASFLP SESGPYGYSN PKILKQSMTL NLADPVGSLK PHLRAKNSDL
LTSPDVGLLK LASPELERLI IQSSNGHITT TPTPTQFLCP KNVTDEQEGF AEGFVRALAE
LHSQNTLPSV TSAAQPVNGA GMVAPAVASV AGGSGSGGFS ASLHSEPPVY ANLSNFNPGA
LSSGGGAPSY GAAGLAFPAQ PQQQQQPPHH LPQQMPVQHP RLQALKEEPQ TVPEMPGETP
PLSPIDMESQ ERIKAERKRM RNRIAASKCR KRKLERIARL EEKVKTLKAQ NSELASTANM
LREQVAQLKQ KVMNHVNSGC QLMLTQQLQT F
Records:
Category Evidence Reference
A Peptide library Wulf GM, Ryo A, Wulf GG, Lee SW, Niu T, Petkova V, Lu KP., Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1., [11432833]
End of Record Details