ul_8609----
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PPBD protein
Gene name PIN1( Description: protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1. )
Synonyms DOD; EC 5.2.1.8; PPIase Pin1; Rotamase Pin1; UBL5
GO annotations GO_component: nucleus [PMID 8606777]
GO_function:isomerase activity; peptidyl-prolyl cis-trans isomerase activity; protein binding [PMID 11470801]
GO_process: cell cycle; protein folding; regulation of mitosis [PMID 10391244]
RefSeq accession NP_006212
SwissProt accession Q13526
Substrate protein
Gene name BCL2
Synonyms
GO annotations GO_component: endoplasmic reticulum; integral to membrane; membrane; mitochondrial outer membrane [PMID 1453000] [PMID 9027314]; mitochondrion; nucleus
GO_function:identical protein binding [PMID 9463381]
GO_process: anti-apoptosis [PMID 9027314] [PMID 11684014]; humoral immune response [PMID 1908951]; negative regulation of cell proliferation [PMID 10848600]; regulation of apoptosis; regulation of progression through cell cycle [PMID 10848600]; release of cytochrome c from mitochondria [PMID 9027314]
RefSeq accession NP_000624
SwissProt accession P10415
GO Pathway:
GO:0006457     protein folding
Sequence:(RefSeq accession:NP_000624; substrate region highlighted if known)
1
61
121
181
MAHAGRTGYD NREIVMKYIH YKLSQRGYEW DAGDVGAAPP GAAPAPGIFS SQPGHTPHPA
ASRDPVARTS PLQTPAAPGA AAGPALSPVP PVVHLTLRQA GDDFSRRYRR DFAEMSSQLH
LTPFTARGRF ATVVEELFRD GVNWGRIVAF FEFGGVMCVE SVNREMSPLV DNIALWMTEY
LNRHLHTWIQ DNGGWDAFVE LYGPSMRPLF DFSWLSLKTL LSLALVGACI TLGAYLGHK
Records:
Category Evidence Reference
A Inference Pathan N, Aime-Sempe C, Kitada S, Basu A, Haldar S, Reed JC., Microtubule-targeting drugs induce bcl-2 phosphorylation and association with Pin1., [11774038]
End of Record Details