ul_891----
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PPBD protein
Gene name YWHAZ
Synonyms KCIP-1; Protein kinase C inhibitor protein 1
GO annotations GO_component:
GO_function:protein domain specific binding; transcription factor binding [PMID 16114898]
GO_process:
RefSeq accession NP_003397
SwissProt accession P63104
Substrate protein
Gene name Irs1( Description: insulin receptor substrate 1. )
Synonyms G972R; IRS-1
GO annotations GO_component: cytoplasm; microsome; nucleus
GO_function:insulin receptor binding; insulin-like growth factor receptor binding; phosphoinositide 3-kinase binding; protein binding; protein kinase binding; receptor activity; SH2 domain binding; signal transducer activity; transmembrane receptor protein tyrosine kinase docking protein activity
GO_process: insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; signal transduction
RefSeq accession NP_034700
SwissProt accession P35569
GO Pathway:
GO:0006605     protein targeting
Sequence:(RefSeq accession:NP_034700; substrate region highlighted if known)
1
61
121
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301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
MASPPDTDGF SDVRKVGYLR KPKSMHKRFF VLRAASEAGG PARLEYYENE KKWRHKSSAP
KRSIPLESCF NINKRADSKN KHLVALYTRD EHFAIAADSE AEQDSWYQAL LQLHNRAKAH
HDGAGGGCGG SCSGSSGVGE AGEDLSYDTG PGPAFKEVWQ VILKPKGLGQ TKNLIGIYRL
CLTSKTISFV KLNSEAAAVV LQLMNIRRCG HSENFFFIEV GRSAVTGPGE FWMQVDDSVV
AQNMHETILE AMRAMSDEFR PRSKSQSSSS CSNPISVPLR RHHLNNPPPS QVGLTRRSRT
ESITATSPAS MVGGKPGSFR VRASSDGEGT MSRPASVDGS PVSPSTNRTH AHRHRGSSRL
HPPLNHSRSI PMPSSRCSPS ATSPVSLSSS STSGHGSTSD CLFPRRSSAS VSGSPSDGGF
ISSDEYGSSP CDFRSSFRSV TPDSLGHTPP ARGEEELSNY ICMGGKGAST LAAPNGHYIL
SRGGNGHRYI PGANLGTSPA LPGDEAAGAA DLDNRFRKRT HSAGTSPTIS HQKTPSQSSV
ASIEEYTEMM PAAYPPGGGS GGRLPGYRHS AFVPTHSYPE EGLEMHHLER RGGHHRPDTS
NLHTDDGYMP MSPGVAPVPS NRKGNGDYMP MSPKSVSAPQ QIINPIRRHP QRVDPNGYMM
MSPSGSCSPD IGGGSSSSSS ISAAPSGSSY GKPWTNGVGG HHTHALPHAK PPVESGGGKL
LPCTGDYMNM SPVGDSNTSS PSECYYGPED PQHKPVLSYY SLPRSFKHTQ RPGEPEEGAR
HQHLRLSSSS GRLRYTATAE DSSSSTSSDS LGGGYCGARP ESSLTHPHHH VLQPHLPRKV
DTAAQTNSRL ARPTRLSLGD PKASTLPRVR EQQQQQQSSL HPPEPKSPGE YVNIEFGSGQ
PGYLAGPATS RSSPSVRCPP QLHPAPREET GSEEYMNMDL GPGRRATWQE SGGVELGRIG
PAPPGSATVC RPTRSVPNSR GDYMTMQIGC PRQSYVDTSP VAPVSYADMR TGIAAEKASL
PRPTGAAPPP SSTASSSVTP QGATAEQATH SSLLGGPQGP GGMSAFTRVN LSPNHNQSAK
VIRADTQGCR RRHSSETFSA PTRAGNTVPF GAGAAVGGSG GGGGGGSEDV KRHSSASFEN
VWLRPGDLGG VSKESAPVCG AAGGLEKSLN YIDLDLAKER SQDCPSQQQS LPPPPPHQPL
GSNEGNSPRR SSEDLSNYAS ISFQKQPEDR Q
Records:
Category Evidence Reference
A Inference Xiang X, Yuan M, Song Y, Ruderman N, Wen R, Luo Z., 14-3-3 facilitates insulin-stimulated intracellular trafficking of insulin receptor substrate 1., [11875115]
End of Record Details