ul_91----
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PPBD protein
Gene name YWHAB( Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide. )
Synonyms GW128; HS1; KCIP-1; Protein 1054; Protein kinase C inhibitor protein 1
GO annotations GO_component: cytoplasm [PMID 12963375]; perinuclear region [PMID 12963375]
GO_function:monooxygenase activity; protein domain specific binding
GO_process:
RefSeq accession NP_003395
SwissProt accession P31946
Substrate protein
Gene name RAF1( Description: v-raf-1 murine leukemia viral oncogene homolog 1. )
Synonyms C-RAF; CRAF; EC 2.7.11.1; Raf-1; c-Raf; cRaf
GO annotations GO_component: mitochondrial outer membrane [PMID 8929532]
GO_function:ATP binding; diacylglycerol binding; metal ion binding; nucleotide binding; protein binding [PMID 9624170] [PMID 10433554]; protein serine/threonine kinase activity; receptor signaling protein activity; transferase activity; zinc ion binding
GO_process: apoptosis [PMID 8929532]; cell proliferation [PMID 8063729]; intracellular signaling cascade; protein amino acid phosphorylation [PMID 8063729]
RefSeq accession NP_002871
SwissProt accession P04049
Sequence:(RefSeq accession:NP_002871; substrate region highlighted if known)
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MEHIQGAWKT ISNGFGFKDA VFDGSSCISP TIVQQFGYQR RASDDGKLTD PSKTSNTIRV
FLPNKQRTVV NVRNGMSLHD CLMKALKVRG LQPECCAVFR LLHEHKGKKA RLDWNTDAAS
LIGEELQVDF LDHVPLTTHN FARKTFLKLA FCDICQKFLL NGFRCQTCGY KFHEHCSTKV
PTMCVDWSNI RQLLLFPNST IGDSGVPALP SLTMRRMRES VSRMPVSSQH RYSTPHAFTF
NTSSPSSEGS LSQRQRSTST PNVHMVSTTL PVDSRMIEDA IRSHSESASP SALSSSPNNL
SPTGWSQPKT PVPAQRERAP VSGTQEKNKI RPRGQRDSSY YWEIEASEVM LSTRIGSGSF
GTVYKGKWHG DVAVKILKVV DPTPEQFQAF RNEVAVLRKT RHVNILLFMG YMTKDNLAIV
TQWCEGSSLY KHLHVQETKF QMFQLIDIAR QTAQGMDYLH AKNIIHRDMK SNNIFLHEGL
TVKIGDFGLA TVKSRWSGSQ QVEQPTGSVL WMAPEVIRMQ DNNPFSFQSD VYSYGIVLYE
LMTGELPYSH INNRDQIIFM VGRGYASPDL SKLYKNCPKA MKRLVADCVK KVKEERPLFP
QILSSIELLQ HSLPKINRSA SEPSLHRAAH TEDINACTLT TSPRLPVF
Records:
Category Evidence Reference
A Mutagenesis Michaud NR, Fabian JR, Mathes KD, Morrison DK., 14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner., [7760835]
End of Record Details