ul_9137----
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PPBD protein
Gene name WWOX
Synonyms AIP3; Atrophin-1-interacting protein 3; BAI1-associated protein 1; BAP-1; MAGI-1; Membrane-associated guanylate kinase inverted 1; Trinucleotide repeat-containing gene 19 protein; WW domain-containing protein 3; WWP3
GO annotations GO_component: cytoplasm [PMID 10786676]; mitochondrion; nucleus
GO_function:coenzyme binding [PMID 10786676]; oxidoreductase activity [PMID 10786676]; protein dimerization activity [PMID 10786676]
GO_process: cell cycle; electron transport [PMID 10786676]; metabolism; negative regulation of progression through cell cycle; steroid metabolism [PMID 10786676]
RefSeq accession NP_057457
SwissProt accession Q96QZ7
Substrate protein
Gene name TP53( Description: tumor protein p53 (Li-Fraumeni syndrome). )
Synonyms Antigen NY-CO-13; LFS1; Phosphoprotein p53; TRP53; Tumor suppressor p53; p53
GO annotations GO_component: cytoplasm [PMID 7720704]; insoluble fraction [PMID 12915590]; mitochondrion [PMID 12667443]; nuclear matrix [PMID 11080164]; nucleolus [PMID 12080348]; nucleoplasm [PMID 11080164] [PMID 12915590]; nucleus [PMID 7720704]
GO_function:ATP binding [PMID 8183576]; copper ion binding [PMID 7824276]; DNA strand annealing activity [PMID 8183576]; enzyme binding [PMID 10666337] [PMID 15577914]; metal ion binding; nuclease activity [PMID 11002423]; protein binding [PMID 15782130]; protein heterodimerization activity [PMID 10837489]; protein N-terminus binding [PMID 11861836]; transcription factor activity [PMID 7587074]; zinc ion binding [PMID 10065153]
GO_process: apoptosis [PMID 7720704]; base-excision repair [PMID 15116721]; caspase activation via cytochrome c [PMID 12667443]; cell aging [PMID 12080348]; cell cycle; cell cycle arrest [PMID 8675009]; cell differentiation [PMID 10065150]; cell proliferation [PMID 10065150]; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis [PMID 14654789]; negative regulation of cell growth [PMID 8986812]; negative regulation of helicase activity [PMID 7663514]; nucleotide-excision repair [PMID 7663514]; protein complex assembly [PMID 12915590]; protein tetramerization [PMID 15116721]; regulation of mitochondrial membrane permeability [PMID 15116721]; regulation of transcription, DNA-dependent [PMID 7587074]; response to DNA damage stimulus [PMID 8986812]; transcription
RefSeq accession NP_000537
SwissProt accession P04637
GO Pathway:
GO:0006917|GO:0009411     induction of apoptosis|response to UV
Sequence:(RefSeq accession:NP_000537; substrate region highlighted if known)
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MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI EQWFTEDPGP
DEAPRMPEAA PRVAPAPAAP TPAAPAPAPS WPLSSSVPSQ KTYQGSYGFR LGFLHSGTAK
SVTCTYSPAL NKMFCQLAKT CPVQLWVDST PPPGTRVRAM AIYKQSQHMT EVVRRCPHHE
RCSDSDGLAP PQHLIRVEGN LRVEYLDDRN TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS
SCMGGMNRRP ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENLR KKGEPHHELP
PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QIRGRERFEM FRELNEALEL KDAQAGKEPG
GSRAHSSHLK SKKGQSTSRH KKLMFKTEGP DSD
Records:
Category Evidence Reference
A Mutagenesis Chang NS, Doherty J, Ensign A, Schultz L, Hsu LJ, Hong Q., WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53., [16219768]
End of Record Details