AQP-2 / TRP channels
Name: Aquaporin-2
(AQP-2)
Official Symbol: AQP2
provided by HGNC
Function:
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
359 |
P41181 |
MINT-7890724 |
106855 |
P41181 |
hsa:359 |
107777 |
|||
|
Mouse
|
11827 |
P56402 |
DIP-58509N |
MINT-7890581 |
198171 |
P56402 |
mmu:11827 |
|||
|
Rat
|
25386 |
P34080 |
DIP-46223N |
247424 |
P34080 |
rno:25386 |
||||
PPI pairs:
Biological Process:
- GO:0030042
: actin filament depolymerization - GO:0007568 : aging
- GO:0006915 : apoptotic process
- GO:0006884 : cell volume homeostasis
- GO:0071280 : cellular response to copper ion
- GO:0071288 : cellular response to mercury ion
- GO:0042631 : cellular response to water deprivation
- GO:0007588 : excretion
- GO:0007565 : female pregnancy
- GO:0006972 : hyperosmotic response
- GO:0072205 : metanephric collecting duct development
- GO:0051928 : positive regulation of calcium ion transport
- GO:0003097 : renal water transport
- GO:0051592 : response to calcium ion
- GO:0033762 : response to glucagon stimulus
- GO:0032496 : response to lipopolysaccharide
- GO:0010226 : response to lithium ion
- GO:0009651 : response to salt stress
- GO:0042594 : response to starvation
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:107777
:
Diabetes insipidus, nephrogenic
(OMIM:125800 )
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPC3 |
|
AQP-2 | Inference | Prediction | 17699554 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPC3 |
|
AQP-2 | Co-immunofluorescence staining | Rat kidney medullary collecting duct | 20107112 | |||||
| TRPC3 |
|
AQP-2 | Co-immunofluorescence staining | Rat kidney duct section | 17699554 | |||||
| TRPC3 |
|
AQP-2 | Co-immunoprecipitation | mIMCD-3 | 17699554 | |||||
| TRPC3 |
|
AQP-2 | Co-immunoprecipitation | Rat medulla lysates | 17699554 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)