BMPR-2 / TRP channels
Name: Bone morphogenetic protein receptor type-2
(BMPR-2)
Official Symbol: BMPR2
provided by HGNC
Function:
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
659 |
Q13873 |
DIP-5794N DIP-5941N DIP-5942N |
Q13873 |
MINT-124272 |
107127 |
Q13873 |
hsa:659 |
600799 |
|
|
Mouse
|
12168 |
O35607 |
DIP-33908N |
O35607 |
MINT-1743993 |
198373 |
O35607 |
mmu:12168 |
||
| Rat | 140590 |
250804 |
rno:140590 |
|||||||
PPI pairs:
Biological Process:
- GO:0009952
: anterior/posterior pattern specification - GO:0060840 : artery development
- GO:0001974 : blood vessel remodeling
- GO:0030509 : BMP signaling pathway
- GO:0007420 : brain development
- GO:0009267 : cellular response to starvation
- GO:0048286 : lung alveolus development
- GO:0001946 : lymphangiogenesis
- GO:0060836 : lymphatic endothelial cell differentiation
- GO:0001707 : mesoderm formation
- GO:0030308 : negative regulation of cell growth
- GO:2000279 : negative regulation of DNA biosynthetic process
- GO:0003085 : negative regulation of systemic arterial blood pressure
- GO:0045906 : negative regulation of vasoconstriction
- GO:0030513 : positive regulation of BMP signaling pathway
- GO:0030501 : positive regulation of bone mineralization
- GO:0010595 : positive regulation of endothelial cell migration
- GO:0001938 : positive regulation of endothelial cell proliferation
- GO:0010634 : positive regulation of epithelial cell migration
- GO:0045669 : positive regulation of osteoblast differentiation
- GO:0010862 : positive regulation of pathway-restricted SMAD protein phosphorylation
- GO:0014916 : regulation of lung blood pressure
- GO:0061298 : retina vasculature development in camera-type eye
- GO:0006366 : transcription from RNA polymerase II promoter
- GO:0048010 : vascular endothelial growth factor receptor signaling pathway
- GO:0060841 : venous blood vessel development
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:600799
:
Pulmonary hypertension, familial primary
(OMIM:178600 )
- OMIM:600799
:
Pulmonary venoocclusive disease
(OMIM:265450 )
- OMIM:600799
:
Pulmonary hypertension, primary, fenfluramine-associated
(OMIM:178600 )
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPC1 |
|
BMPR-2 | Affinity purification-mass spectrometry | Not used as a bait | Mouse | Leg muscle | C2C12 lysates | 15188402 | ||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)