CDKAL1 / TRP channels
Name: Threonylcarbamoyladenosine tRNA methylthiotransferase
(CDKAL1)
Official Symbol: CDKAL1
provided by HGNC
Function:
Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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54901![]() |
Q5VV42![]() |
120247![]() |
Q5VV42![]() |
hsa:54901![]() |
611259![]() |
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Mouse
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68916![]() |
Q91WE6![]() |
213112![]() |
Q91WE6![]() |
mmu:68916![]() |
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Rat | 361243![]() |
262543![]() |
rno:361243![]() |
PPI pairs:
Biological Process:
- GO:0009451
: RNA modification
- GO:0008033
: tRNA processing
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:611259
: Diabetes mellitus, noninsulin-dependent, susceptibility to (OMIM:125853
)
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPP1 |
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CDKAL1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
