CaBP1 / TRP channels
Name: Calcium-binding protein 1
(CaBP1)
Official Symbol: CABP1
provided by HGNC
Function:
Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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9478![]() |
Q9NZU7![]() |
DIP-35477N![]() |
Q9NZU7![]() |
114863![]() |
Q9NZU7![]() |
hsa:9478![]() |
605563![]() |
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Mouse
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29867![]() |
Q9JLK7![]() |
205933![]() |
Q9JLK7![]() |
mmu:29867![]() |
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Rat
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171051![]() |
O88751![]() |
DIP-46059N![]() |
O88751![]() |
251068![]() |
O88751![]() |
rno:171051![]() |
PPI pairs:
Biological Process:
No information in Gene Ontology
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPC5 |
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CaBP1 | Inference | Prediction | 15895247 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vitro validation
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Assay with recombinant proteins | Reference | |||||||||
TRP channel construct | Interactor construct | |||||||||
TRP channel | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system | ||
TRPC5 |
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CaBP1 | Fusion protein-pull down assay | Mouse | Full-length | E. coli | Human | Full-length | E. coli | 15895247 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Characterization
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Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | |||||||
TRP channel | Interactor | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPC5 |
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CaBP1 | Fusion protein-pull down assay | Mouse | 1-331 | Human | Not determined | 15895247 | ||
TRPC5 |
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CaBP1 | Fusion protein-pull down assay | Mouse | 721-817 | Human | Not determined | 15895247 | ||
TRPC5 |
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CaBP1 | Fusion protein-pull down assay | Mouse | 791-866 | Human | Not determined | 15895247 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Functional consequence
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TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | ||||||
TRPC5 |
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CaBP1 | Patch clamp | Inhibition | 15895247 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
