CaSR / TRP channels
Name: Extracellular calcium-sensing receptor
(CaSR)
Official Symbol: CASR
provided by HGNC
Function:
Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
846 |
P41180 |
DIP-5975N |
P41180 |
107296 |
P41180 |
hsa:846 |
601199 |
||
|
Mouse
|
12374 |
Q9QY96 |
198504 |
Q9QY96 |
mmu:12374 |
|||||
|
Rat
|
24247 |
P48442 |
P48442 |
246432 |
P48442 |
rno:24247 |
||||
PPI pairs:
Biological Process:
- GO:0009653
: anatomical structure morphogenesis - GO:0070509 : calcium ion import
- GO:0006874 : cellular calcium ion homeostasis
- GO:0007635 : chemosensory behavior
- GO:0005513 : detection of calcium ion
- GO:0001503 : ossification
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:601199
:
Hypocalciuric hypercalcemia, type I
(OMIM:145980 )
- OMIM:601199
:
Hyperparathyroidism, neonatal
(OMIM:239200 )
- OMIM:601199
:
Hypocalcemia, autosomal dominant
(OMIM:146200 )
- OMIM:601199
:
Hypocalcemia, autosomal dominant, with Bartter syndrome
(OMIM: )
- OMIM:601199
:
Epilepsy, idiopathic generalized, susceptibility to, 8
(OMIM:612899 )
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
Screening
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPC3 |
|
CaSR | Inference | Prediction | 22778254 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPC3 |
|
CaSR | Co-immunofluorescence staining | Mouse submandibular gland (SMG) ductal tissue section | 22778254 | |||||
| TRPC3 |
|
CaSR | Co-immunoprecipitation | Mouse submandibular gland (SMG) ductal cell lysates | 22778254 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Functional consequence
|
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | ||||||
| TRPC3 |
|
CaSR | Cell surface biotinylation | Increase in plasma membrane level | 22778254 | |||||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)