Calnexin / TRP channels
Name: Calnexin
(Calnexin)
Official Symbol: CANX
provided by HGNC
Function:
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
821 |
P27824 |
DIP-457N |
P27824 |
MINT-5000964 |
107271 |
P27824 |
hsa:821 |
114217 |
|
|
Mouse
|
12330 |
P35564 |
DIP-32165N |
P35564 |
MINT-1862151 |
198467 |
P35564 |
mmu:12330 |
||
|
Rat
|
29144 |
P35565 |
DIP-36923N |
P35565 |
MINT-4996673 |
247827 |
P35565 |
rno:29144 |
||
PPI pairs:
Biological Process:
- GO:0007568
: aging - GO:0019886 : antigen processing and presentation of exogenous peptide antigen via MHC class II
- GO:0002474 : antigen processing and presentation of peptide antigen via MHC class I
- GO:0072583 : clathrin-mediated endocytosis
- GO:0043687 : post-translational protein modification
- GO:0006457 : protein folding
- GO:0018279 : protein N-linked glycosylation via asparagine
- GO:0009306 : protein secretion
- GO:0048488 : synaptic vesicle endocytosis
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPP1 |
|
Calnexin | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
(:
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:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)