TRP channels

TRPC
- TRPC1
- TRPC2
- TRPC3
- TRPC4
- TRPC5
- TRPC6
- TRPC7
TRPV
- TRPV1
- TRPV2
- TRPV3
- TRPV4
- TRPV5
- TRPV6
TRPM
- TRPM1
- TRPM2
- TRPM3
- TRPM4
- TRPM5
- TRPM6
- TRPM7
- TRPM8
TRPML
- TRPML1
- TRPML2
- TRPML3
TRPP
- TRPP1
- TRPP2
- TRPP3
TRPA
- TRPA1

» Citation

Nar2011 9c5ccb7544ea9ea0a4b3599ccec8bea610f3995142d5da2da0189fad9f699236

Plos2012 71954aaff6a4569630a779eb6502d687ff86630adfca3a1cc207b9836b808980

Pf2013 33c9f49bb4f61555bed5365c90448ebe56e96eb338f5692f7ef4b8a5db693247

Calreticulin / TRP channels

Basic Information
External Database
PPI pairs (1)
Biological Process (34)
Disease (0)

Name: Calreticulin (Calreticulin)

Official Symbol: CALR provided by HGNC

Function:

Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).

Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species

External DB

Questionmark c7dcdfe7852228a510704064c33a0706d8c0e915bceea718517e77f7950c2984

Entrez Gene

UniprotKB

DIP

IntAct

MINT

BioGRID

STRING

IUPHAR-DB

KEGG

OMIM

Human

Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f

Mouse

Rat

PPI pairs:

Biological Process:

GO:0006987 : activation of signaling protein activity involved in unfolded protein response
GO:0002479 : antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0055007 : cardiac muscle cell differentiation
GO:0007050 : cell cycle arrest
GO:0071285 : cellular response to lithium ion
GO:0090398 : cellular senescence
GO:0030866 : cortical actin cytoskeleton organization
GO:0042921 : glucocorticoid receptor signaling pathway
GO:0033144 : negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0045665 : negative regulation of neuron differentiation
GO:0048387 : negative regulation of retinoic acid receptor signaling pathway
GO:0000122 : negative regulation of transcription from RNA polymerase II promoter
GO:0017148 : negative regulation of translation
GO:0002502 : peptide antigen assembly with MHC class I protein complex
GO:0045787 : positive regulation of cell cycle
GO:0008284 : positive regulation of cell proliferation
GO:2000510 : positive regulation of dendritic cell chemotaxis
GO:0045740 : positive regulation of DNA replication
GO:0010628 : positive regulation of gene expression
GO:0050766 : positive regulation of phagocytosis
GO:1900026 : positive regulation of substrate adhesion-dependent cell spreading
GO:0043687 : post-translational protein modification
GO:0006611 : protein export from nucleus
GO:0034504 : protein localization to nucleus
GO:0022417 : protein maturation by protein folding
GO:0018279 : protein N-linked glycosylation via asparagine
GO:0050821 : protein stabilization
GO:0042981 : regulation of apoptotic process
GO:0040020 : regulation of meiosis
GO:0042493 : response to drug
GO:0032355 : response to estradiol stimulus
GO:0033574 : response to testosterone stimulus
GO:0051208 : sequestering of calcium ion
GO:0007283 : spermatogenesis

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/

Disease: No information in OMIM

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Screening

Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Functional consequence

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Screening
			Experimental screening					Non-experimental screening	Reference
			TRP channel construct		Interactor source
TRP channel	Interactor	Method	Species	Region	Species	Organ/tissue	Sample type
TRPC3	Calreticulin	Inference						Prediction	18215135

(

Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4

: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening

Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Functional consequence

top

Validation: In vivo validation
			Assay with endogenous proteins	Assay with overexpressed proteins					Reference
			Cell or tissue	Cell or tissue	TRP channel construct		Interactor construct
TRP channel	Interactor	Method	Cell or tissue	Cell or tissue	Species	Region	Species	Region
TRPC3	Calreticulin	Co-immunoprecipitation	Mouse skeletal myotube lysates						18215135

(

: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

TRIP Database

Calreticulin / TRP channels