Caspase-1 / TRP channels
Name: Caspase-1
(Caspase-1)
Official Symbol: CASP1
provided by HGNC
Function:
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. {ECO:0000269|PubMed:15498465, ECO:0000269|PubMed:7876192}.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
834 |
P29466 |
DIP-175N |
P29466 |
MINT-201196 |
107284 |
P29466 |
hsa:834 |
147678 |
|
|
Mouse
|
12362 |
P29452 |
DIP-34659N |
P29452 |
P29452 |
mmu:12362 |
||||
|
Rat
|
P43527 |
DIP-29840N |
P43527 |
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PPI pairs:
Biological Process:
- GO:0006919
: activation of cysteine-type endopeptidase activity involved in apoptotic process - GO:0006915 : apoptotic process
- GO:0071260 : cellular response to mechanical stimulus
- GO:0071310 : cellular response to organic substance
- GO:0097194 : execution phase of apoptosis
- GO:0045087 : innate immune response
- GO:0032611 : interleukin-1 beta production
- GO:0060081 : membrane hyperpolarization
- GO:0051882 : mitochondrial depolarization
- GO:0035872 : nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
- GO:0043123 : positive regulation of I-kappaB kinase/NF-kappaB signaling
- GO:0050717 : positive regulation of interleukin-1 alpha secretion
- GO:0050718 : positive regulation of interleukin-1 beta secretion
- GO:0006508 : proteolysis
- GO:0070269 : pyroptosis
- GO:0050727 : regulation of inflammatory response
- GO:0033198 : response to ATP
- GO:0001666 : response to hypoxia
- GO:0032496 : response to lipopolysaccharide
- GO:0007165 : signal transduction
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPC1 |
|
Caspase-1 | Speculation | Prediction | 24630989 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPC1 |
|
Caspase-1 | Co-immunoprecipitation | HEK293T | Not specified | Full-length | Not specified | Full-length | 24630989 | |
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)