Caveolin-3 / TRP channels
Name: Caveolin-3
(Caveolin-3)
Official Symbol: CAV3
provided by HGNC
Function:
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
859 |
P56539 |
P56539 |
MINT-3021471 |
107307 |
P56539 |
hsa:859 |
601253 |
||
|
Mouse
|
12391 |
P51637 |
DIP-31069N |
P51637 |
MINT-2982959 |
198516 |
P51637 |
mmu:12391 |
||
|
Rat
|
29161 |
P51638 |
DIP-40859N |
MINT-145738 |
247843 |
P51638 |
rno:29161 |
|||
PPI pairs:
Biological Process:
- GO:0070836
: caveola assembly - GO:0016049 : cell growth
- GO:0042632 : cholesterol homeostasis
- GO:0007204 : elevation of cytosolic calcium ion concentration
- GO:0042593 : glucose homeostasis
- GO:0046716 : muscle cell homeostasis
- GO:0007517 : muscle organ development
- GO:0051926 : negative regulation of calcium ion transport
- GO:0010614 : negative regulation of cardiac muscle hypertrophy
- GO:0045792 : negative regulation of cell size
- GO:0043407 : negative regulation of MAP kinase activity
- GO:0051001 : negative regulation of nitric-oxide synthase activity
- GO:0060299 : negative regulation of sarcomere organization
- GO:0031116 : positive regulation of microtubule polymerization
- GO:0072659 : protein localization to plasma membrane
- GO:0090279 : regulation of calcium ion import
- GO:1901019 : regulation of calcium ion transmembrane transporter activity
- GO:0055117 : regulation of cardiac muscle contraction
- GO:0002027 : regulation of heart rate
- GO:1900825 : regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential
- GO:0051394 : regulation of nerve growth factor receptor activity
- GO:0038009 : regulation of signal transduction by receptor internalization
- GO:0014819 : regulation of skeletal muscle contraction
- GO:2000649 : regulation of sodium ion transmembrane transporter activity
- GO:0060373 : regulation of ventricular cardiac muscle cell membrane depolarization
- GO:0060307 : regulation of ventricular cardiac muscle cell membrane repolarization
- GO:0033292 : T-tubule organization
- GO:0006641 : triglyceride metabolic process
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:601253
:
Muscular dystrophy, limb-girdle, type IC
(OMIM:607801 )
- OMIM:601253
:
Rippling muscle disease
(OMIM:606072 )
- OMIM:601253
:
Creatine phosphokinase, elevated serum
(OMIM:123320 )
- OMIM:601253
:
Myopathy, distal, Tateyama type
(OMIM:614321 )
- OMIM:601253
:
Cardiomyopathy, familial hypertrophic
(OMIM:192600 )
- OMIM:601253
:
Long QT syndrome-9
(OMIM:611818 )
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
Screening
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPC1 |
|
Caveolin-3 | Inference | Prediction | 18544631 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPC1 |
|
Caveolin-3 | Co-immunofluorescence staining | Mouse skeletal muscle section | 18544631 | |||||
| TRPC1 |
|
Caveolin-3 | Co-immunoprecipitation | Mouse skeletal muscle cell | 18544631 | |||||
| TRPC1 |
|
Caveolin-3 | Fluorescence resonance energy transfer | Mouse skeletal muscle | Human | Full-length | Mouse | Full-length | 18544631 | |
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)