Clathrin-H1 / TRP channels
Name: Clathrin heavy chain 1
(Clathrin-H1)
Official Symbol: CLTC
provided by HGNC
Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
1213 |
Q00610 |
DIP-32514N |
Q00610 |
MINT-4998595 |
107623 |
Q00610 |
hsa:1213 |
118955 |
|
|
Mouse
|
67300 |
Q68FD5 |
DIP-31947N |
Q68FD5 |
MINT-4153227 |
212086 |
Q68FD5 |
mmu:67300 |
||
|
Rat
|
54241 |
P11442 |
DIP-36966N |
P11442 |
MINT-93121 |
248464 |
P11442 |
rno:54241 |
||
Biological Process:
- GO:0019886
: antigen processing and presentation of exogenous peptide antigen via MHC class II - GO:0007411 : axon guidance
- GO:0016044 : cellular membrane organization
- GO:0007173 : epidermal growth factor receptor signaling pathway
- GO:0006886 : intracellular protein transport
- GO:0007067 : mitosis
- GO:0042059 : negative regulation of epidermal growth factor receptor signaling pathway
- GO:0048011 : nerve growth factor receptor signaling pathway
- GO:0006892 : post-Golgi vesicle-mediated transport
- GO:0031623 : receptor internalization
- GO:0033572 : transferrin transport
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
Screening
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|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPC3 |
|
Clathrin-H1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC5 |
|
Clathrin-H1 | Affinity purification-mass spectrometry | Endogenous protein | Rat | Brain | Cerebral cortex lysates | 16025302 | ||
| TRPC6 |
|
Clathrin-H1 | Speculation | Prediction | 16025302 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPC3 |
|
Clathrin-H1 | Co-immunoprecipitation | Rat brain lysates | 18205297 | |||||
| TRPC5 |
|
Clathrin-H1 | Co-immunoprecipitation | Rat brain lysates | 16025302 | |||||
| TRPC6 |
|
Clathrin-H1 | Co-immunoprecipitation | Rat brain lysates | 16025302 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)