Contactin-1 / TRP channels
Name: Contactin-1
(Contactin-1)
Official Symbol: CNTN1
provided by HGNC
Function:
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
![]() |
1272![]() |
Q12860![]() |
Q12860![]() |
107672![]() |
Q12860![]() |
hsa:1272![]() |
600016![]() |
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Mouse
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12805![]() |
P12960![]() |
DIP-32016N![]() |
P12960![]() |
MINT-1177246![]() |
198797![]() |
P12960![]() |
mmu:12805![]() |
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Rat
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117258![]() |
Q63198![]() |
DIP-53082N![]() |
Q63198![]() |
MINT-4598466![]() |
250705![]() |
Q63198![]() |
rno:117258![]() |
PPI pairs:
Biological Process:
- GO:0007411
: axon guidance
- GO:0007155
: cell adhesion
- GO:0007219
: Notch signaling pathway
- GO:0010628
: positive regulation of gene expression
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:600016
: Myopathy, congenital, Compton-North (OMIM:612540
)
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPV1 |
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Contactin-1 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library | 17074976 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
