DAP-150 / TRP channels
Name: Dynactin subunit 1
(DAP-150)
Official Symbol: DCTN1
provided by HGNC
Function:
Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
1639 |
Q14203 |
DIP-31365N |
Q14203 |
MINT-5004548 |
108007 |
Q14203 |
hsa:1639 |
601143 |
|
|
Mouse
|
13191 |
O08788 |
DIP-46320N |
O08788 |
MINT-1847327 |
199072 |
O08788 |
mmu:13191 |
||
|
Rat
|
29167 |
P28023 |
DIP-44817N |
MINT-1531595 |
247848 |
P28023 |
rno:29167 |
|||
PPI pairs:
Biological Process:
- GO:0006987
: activation of signaling protein activity involved in unfolded protein response - GO:0019886 : antigen processing and presentation of exogenous peptide antigen via MHC class II
- GO:0008219 : cell death
- GO:0000086 : G2/M transition of mitotic cell cycle
- GO:0007067 : mitosis
- GO:0007399 : nervous system development
- GO:0006810 : transport
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:601143
:
Neuropathy, distal hereditary motor, type VIIB
(OMIM:607641 )
- OMIM:601143
:
Amyotrophic lateral sclerosis, susceptibility to
(OMIM:105400 )
- OMIM:601143
:
Perry syndrome
(OMIM:168605 )
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
|
Screening
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|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPV1 |
|
DAP-150 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library | 17074976 | |
(:
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:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)