DRP-2 / TRP channels
Name: Dihydropyrimidinase-related protein 2
(DRP-2)
Official Symbol: DPYSL2
provided by HGNC
Function:
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
1808 |
Q16555 |
Q16555 |
MINT-3032752 |
108142 |
Q16555 |
hsa:1808 |
602463 |
||
|
Mouse
|
12934 |
O08553 |
O08553 |
198891 |
O08553 |
mmu:12934 |
||||
|
Rat
|
25416 |
P47942 |
P47942 |
MINT-224453 |
247451 |
P47942 |
rno:25416 |
|||
PPI pairs:
Biological Process:
- GO:0007411
: axon guidance - GO:0007010 : cytoskeleton organization
- GO:0006139 : nucleobase-containing compound metabolic process
- GO:0021772 : olfactory bulb development
- GO:0014049 : positive regulation of glutamate secretion
- GO:0006208 : pyrimidine nucleobase catabolic process
- GO:0045664 : regulation of neuron differentiation
- GO:0001975 : response to amphetamine
- GO:0042220 : response to cocaine
- GO:0042493 : response to drug
- GO:0007165 : signal transduction
- GO:0021510 : spinal cord development
- GO:0048489 : synaptic vesicle transport
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPC3 |
|
DRP-2 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPC3 |
|
DRP-2 | Co-immunoprecipitation | Rat brain lysates | 18205297 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)