Dynamin-1L / TRP channels

Name: Dynamin-1-like protein (Dynamin-1L)
Official Symbol: DNM1L provided by HGNC
Function:
Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into ring-like structures which wrap around the scission site to constict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Required for normal brain development. Facilitates developmentally-regulated apoptosis during neural tube development. Required for a normal rate of cytochrome c release and caspase activation during apoptosis. Also required for mitochondrial fission during mitosis. Required for programmed necrosis execution. May be involved in vesicle transport.Isoform 1 and isoform 4 inhibit peroxisomal division when overexpressed.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark c7dcdfe7852228a510704064c33a0706d8c0e915bceea718517e77f7950c2984
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f 		10059External O00429External   O00429External MINT-1394198External 115370External O00429External   hsa:10059External 603850External
Mouse
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f 		74006External Q8K1M6External   Q8K1M6External   216417External Q8K1M6External   mmu:74006External  
Rat
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f 		114114External O35303External DIP-29699NExternal O35303External MINT-4582542External 250292External O35303External   rno:114114External  
PPI pairs:
Biological Process:
  • GO:0006921 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : cellular component disassembly involved in execution phase of apoptosis
  • GO:0003374 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : dynamin polymerization involved in mitochondrial fission
  • GO:0006184 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : GTP catabolic process
  • GO:0090149 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : membrane fission involved in mitochondrial fission
  • GO:0043653 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : mitochondrial fragmentation involved in apoptotic process
  • GO:0070584 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : mitochondrion morphogenesis
  • GO:0016559 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : peroxisome fission
  • GO:2001244 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : positive regulation of intrinsic apoptotic signaling pathway
  • GO:0090141 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : positive regulation of mitochondrial fission
  • GO:0050714 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : positive regulation of protein secretion
  • GO:0090200 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : positive regulation of release of cytochrome c from mitochondria
  • GO:0051289 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : protein homotetramerization
  • GO:1900063 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : regulation of peroxisome organization
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Screening Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Functional consequence Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b top
Screening Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPC3 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Dynamin-1L Affinity purification-mass spectrometry Not used as a bait Rat Brain Crude membranes 18205297
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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