Dystrophin / TRP channels

Name: Dystrophin (Dystrophin)
Official Symbol: DMD provided by HGNC
Function:
Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark c7dcdfe7852228a510704064c33a0706d8c0e915bceea718517e77f7950c2984
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f 		1756External P11532External DIP-32593NExternal P11532External MINT-109755External 108096External P11532External   hsa:1756External 300377External
Mouse
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f 		13405External P11531External DIP-32899NExternal P11531External MINT-85369External 199245External P11531External   mmu:13405External  
Rat
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f 		24907External P11530External DIP-33674NExternal P11530External UNK-5371352External 247015External P11530External   rno:24907External  
PPI pairs:
Biological Process:
  • GO:0060048 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : cardiac muscle contraction
  • GO:0043623 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : cellular protein complex assembly
  • GO:0046716 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : muscle cell homeostasis
  • GO:0030049 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : muscle filament sliding
  • GO:0007517 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : muscle organ development
  • GO:0033137 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : negative regulation of peptidyl-serine phosphorylation
  • GO:0048812 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : neuron projection morphogenesis
  • GO:0045213 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : neurotransmitter receptor metabolic process
  • GO:0021629 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : olfactory nerve structural organization
  • GO:0043043 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : peptide biosynthetic process
  • GO:0086001 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : regulation of cardiac muscle cell action potential
  • GO:0010881 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
  • GO:0002027 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : regulation of heart rate
  • GO:2000169 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : regulation of peptidyl-cysteine S-nitrosylation
  • GO:0060314 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : regulation of ryanodine-sensitive calcium-release channel activity
  • GO:0014809 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
  • GO:0006355 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : regulation of transcription, DNA-dependent
  • GO:0007519 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : skeletal muscle tissue development
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Screening Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Functional consequence Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b top
Screening Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPC1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Dystrophin Inference Prediction 17202249
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Screening Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Functional consequence Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b top
Validation: In vivo validation Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPC1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Dystrophin Co-immunofluorescence staining SolC57 17202249
TRPC1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Dystrophin Co-immunoprecipitation Mouse hind limb muscle 17202249
TRPC1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Dystrophin Co-immunoprecipitation SolC57 17202249
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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