Ezrin / TRP channels
Name: Ezrin
(Ezrin)
Official Symbol: EZR
provided by HGNC
Function:
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species | External DB | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
7430 | P15311 | DIP-38868N | P15311 | MINT-195721 | 113271 | P15311 | hsa:7430 | 123900 | |
Mouse
|
22350 | P26040 | DIP-38079N | P26040 | MINT-1708640 | 204522 | P26040 | mmu:22350 | ||
Rat
|
54319 | P31977 | DIP-36908N | P31977 | MINT-4570080 | 248535 | P31977 | rno:54319 |
PPI pairs:
Biological Process:
- GO:0051017 : actin filament bundle assembly
- GO:0007411 : axon guidance
- GO:0007016 : cytoskeletal anchoring at plasma membrane
- GO:0030855 : epithelial cell differentiation
- GO:0035088 : establishment or maintenance of apical/basal cell polarity
- GO:0007159 : leukocyte cell-cell adhesion
- GO:0022614 : membrane to membrane docking
- GO:0008360 : regulation of cell shape
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top |
Screening | ||||||||||
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPC3 | Ezrin | Inference | Prediction | 11524429 |
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top |
Validation: In vivo validation | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPC3 | Ezrin | Co-immunoprecipitation | HEK293 | Human | Full-length | Not used | 11524429 |
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)