FAF1 / TRP channels
Name: FAS-associated factor 1
(FAF1)
Official Symbol: FAF1
provided by HGNC
Function:
Potentiates but cannot initiate FAS-induced apoptosis.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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11124![]() |
Q9UNN5![]() |
DIP-38245N![]() |
Q9UNN5![]() |
MINT-88745![]() |
116298![]() |
Q9UNN5![]() |
hsa:11124![]() |
604460![]() |
|
Mouse
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14084![]() |
P54731![]() |
DIP-41606N![]() |
MINT-1513304![]() |
199588![]() |
P54731![]() |
mmu:14084![]() |
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Rat
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140657![]() |
Q924K2![]() |
UNK-5532353![]() |
250821![]() |
Q924K2![]() |
rno:140657![]() |
PPI pairs:
Biological Process:
- GO:0006915
: apoptotic process
- GO:0008219
: cell death
- GO:0007253
: cytoplasmic sequestering of NF-kappaB
- GO:0043065
: positive regulation of apoptotic process
- GO:0031334
: positive regulation of protein complex assembly
- GO:0043161
: proteasomal ubiquitin-dependent protein catabolic process
- GO:0030155
: regulation of cell adhesion
- GO:0042176
: regulation of protein catabolic process
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPV1 |
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FAF1 | Yeast two-hybrid | Rat | 243-440 | Rat | Sensory neuron | cDNA expression library | 16510717 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
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Validation: In vitro validation
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Assay with recombinant proteins | Reference | |||||||||
TRP channel construct | Interactor construct | |||||||||
TRP channel | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system | ||
TRPV1 |
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FAF1 | Fusion protein-pull down assay | Rat | 1-440 | E. coli | Rat | Full-length | E. coli | 16510717 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
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Validation: In vivo validation
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Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPV1 |
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FAF1 | Co-immunofluorescence staining | Rat dorsal root ganglion cell | 16510717 | |||||
TRPV1 |
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FAF1 | Co-immunoprecipitation | Rat dorsal root ganglion cell | 16510717 | |||||
TRPV1 |
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FAF1 | Co-immunoprecipitation | HEK293T | Rat | Full-length | Rat | Full-length | 16510717 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
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Characterization
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Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | |||||||
TRP channel | Interactor | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPV1 |
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FAF1 | Fusion protein-pull down assay | Rat | 243-440 | Rat | 110-169 | 16510717 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Functional consequence
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TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | ||||||
TRPV1 |
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FAF1 | Calcium measurement | Inhibition | 16510717 | |||||||
TRPV1 |
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FAF1 | Patch clamp | Inhibition | 16510717 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
