Filamin-A / TRP channels
Name: Filamin-A
(Filamin-A)
Official Symbol: FLNA
provided by HGNC
Function:
Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
2316 |
P21333 |
DIP-1136N |
P21333 |
MINT-118283 |
108605 |
P21333 |
hsa:2316 |
300017 |
|
|
Mouse
|
192176 |
Q8BTM8 |
DIP-44114N |
Q8BTM8 |
MINT-1867095 |
228662 |
Q8BTM8 |
mmu:192176 |
||
|
Rat
|
293860 |
C0JPT7 |
C0JPT7 |
254490 |
C0JPT7 |
rno:293860 |
||||
PPI pairs:
Biological Process:
- GO:0051764
: actin crosslink formation - GO:0031532 : actin cytoskeleton reorganization
- GO:0007195 : adenylate cyclase-inhibiting dopamine receptor signaling pathway
- GO:0034329 : cell junction assembly
- GO:0042384 : cilium assembly
- GO:0051220 : cytoplasmic sequestering of protein
- GO:0045022 : early endosome to late endosome transport
- GO:0001837 : epithelial to mesenchymal transition
- GO:0045184 : establishment of protein localization
- GO:0042177 : negative regulation of protein catabolic process
- GO:0043433 : negative regulation of sequence-specific DNA binding transcription factor activity
- GO:0030168 : platelet activation
- GO:0002576 : platelet degranulation
- GO:0043123 : positive regulation of I-kappaB kinase/NF-kappaB cascade
- GO:0042993 : positive regulation of transcription factor import into nucleus
- GO:0034394 : protein localization to cell surface
- GO:0050821 : protein stabilization
- GO:0043113 : receptor clustering
- GO:0090307 : spindle assembly involved in mitosis
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:300017
:
Heterotopia, periventricular
(OMIM:300049 )
- OMIM:300017
:
Otopalatodigital syndrome, type I
(OMIM:311300 )
- OMIM:300017
:
Otopalatodigital syndrome, type II
(OMIM:304120 )
- OMIM:300017
:
Intestinal pseudoobstruction, neuronal
(OMIM:300048 )
- OMIM:300017
:
Melnick-Needles syndrome
(OMIM:309350 )
- OMIM:300017
:
Frontometaphyseal dysplasia
(OMIM:305620 )
- OMIM:300017
:
Heterotopia, periventricular, ED variant
(OMIM:300537 )
- OMIM:300017
:
FG syndrome 2
(OMIM:300321 )
- OMIM:300017
:
Cardiac valvular dysplasia, X-linked
(OMIM:314400 )
- OMIM:300017
:
Terminal osseous dysplasia
(OMIM:300244 )
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPP1 |
|
Filamin-A | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPP1 |
|
Filamin-A | Co-immunoprecipitation | COS-7 | 19879844 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)