GLUD1 / TRP channels
Name: Glutamate dehydrogenase 1, mitochondrial
(GLUD1)
Official Symbol: GLUD1
provided by HGNC
Function:
May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species | External DB | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
2746 | P00367 | P00367 | MINT-5005913 | 109008 | P00367 | hsa:2746 | 138130 | ||
Mouse
|
14661 | P26443 | P26443 | 199956 | P26443 | mmu:14661 | ||||
Rat
|
24399 | P10860 | P10860 | MINT-2793533 | 246566 | P10860 | rno:24399 |
PPI pairs:
Biological Process:
- GO:0034641 : cellular nitrogen compound metabolic process
- GO:0006537 : glutamate biosynthetic process
- GO:0006538 : glutamate catabolic process
- GO:0032024 : positive regulation of insulin secretion
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:138130 : Hyperinsulinism-hyperammonemia syndrome (OMIM:606762 )
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top |
Screening | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPC3 | GLUD1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 |
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)