GLUD1 / TRP channels
Name: Glutamate dehydrogenase 1, mitochondrial
(GLUD1)
Official Symbol: GLUD1
provided by HGNC
Function:
May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
2746 |
P00367 |
P00367 |
MINT-5005913 |
109008 |
P00367 |
hsa:2746 |
138130 |
||
Mouse
|
14661 |
P26443 |
P26443 |
199956 |
P26443 |
mmu:14661 |
||||
Rat
|
24399 |
P10860 |
P10860 |
MINT-2793533 |
246566 |
P10860 |
rno:24399 |
|||
PPI pairs:
Biological Process:
- GO:0034641
: cellular nitrogen compound metabolic process - GO:0006537
: glutamate biosynthetic process - GO:0006538
: glutamate catabolic process - GO:0032024
: positive regulation of insulin secretion
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:138130
:
Hyperinsulinism-hyperammonemia syndrome
(OMIM:606762
)
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPC3 |
|
GLUD1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)







Screening