Galectin-1 / TRP channels
Name: Galectin-1
(Galectin-1)
Official Symbol: LGALS1
provided by HGNC
Function:
May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
3956 |
P09382 |
DIP-46153N |
P09382 |
MINT-3306493 |
110147 |
P09382 |
hsa:3956 |
150570 |
|
|
Mouse
|
16852 |
P16045 |
DIP-51733N |
P16045 |
MINT-4100323 |
201142 |
mmu:16852 |
|||
|
Rat
|
56646 |
P11762 |
DIP-37188N |
P11762 |
MINT-4587374 |
248567 |
P11762 |
rno:56646 |
||
PPI pairs:
Biological Process:
- GO:0006915
: apoptotic process - GO:0071333 : cellular response to glucose stimulus
- GO:0071407 : cellular response to organic cyclic compound
- GO:0033555 : multicellular organismal response to stress
- GO:0045445 : myoblast differentiation
- GO:0010812 : negative regulation of cell-substrate adhesion
- GO:0010977 : negative regulation of neuron projection development
- GO:0002317 : plasma cell differentiation
- GO:0034120 : positive regulation of erythrocyte aggregation
- GO:0043123 : positive regulation of I-kappaB kinase/NF-kappaB signaling
- GO:0042981 : regulation of apoptotic process
- GO:0048678 : response to axon injury
- GO:0042493 : response to drug
- GO:0031295 : T cell costimulation
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPV5 |
|
Galectin-1 | Inference | Prediction | 18606998 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPV5 |
|
Galectin-1 | Co-immunoprecipitation | HEK293 | Rabbit | Full-length | Not used | 18606998 | ||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)