HCK / TRP channels
Name: Tyrosine-protein kinase HCK
(HCK)
Official Symbol: HCK
provided by HGNC
Function:
Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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3055![]() |
P08631![]() |
DIP-1051N![]() |
P08631![]() |
MINT-135300![]() |
109305![]() |
P08631![]() |
hsa:3055![]() |
142370![]() |
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Mouse
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15162![]() |
P08103![]() |
DIP-57107N![]() |
MINT-4097288![]() |
200249![]() |
P08103![]() |
mmu:15162![]() |
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Rat
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25734![]() |
P50545![]() |
MINT-4592593![]() |
247762![]() |
P50545![]() |
rno:25734![]() |
PPI pairs:
Biological Process:
- GO:0007155
: cell adhesion
- GO:0050830
: defense response to Gram-positive bacterium
- GO:0006954
: inflammatory response
- GO:0002758
: innate immune response-activating signal transduction
- GO:0007229
: integrin-mediated signaling pathway
- GO:0060333
: interferon-gamma-mediated signaling pathway
- GO:0043299
: leukocyte degranulation
- GO:0002522
: leukocyte migration involved in immune response
- GO:0031663
: lipopolysaccharide-mediated signaling pathway
- GO:0007498
: mesoderm development
- GO:0043066
: negative regulation of apoptotic process
- GO:0018108
: peptidyl-tyrosine phosphorylation
- GO:0006909
: phagocytosis
- GO:2000251
: positive regulation of actin cytoskeleton reorganization
- GO:0030838
: positive regulation of actin filament polymerization
- GO:0008284
: positive regulation of cell proliferation
- GO:0046777
: protein autophosphorylation
- GO:0008360
: regulation of cell shape
- GO:0050690
: regulation of defense response to virus by virus
- GO:0050727
: regulation of inflammatory response
- GO:0050764
: regulation of phagocytosis
- GO:0071801
: regulation of podosome assembly
- GO:0051090
: regulation of sequence-specific DNA binding transcription factor activity
- GO:0045728
: respiratory burst after phagocytosis
- GO:0016032
: viral reproduction
- GO:0019048
: virus-host interaction
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPV4 |
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HCK | Inference | Prediction | 12538589 |
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:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
![Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4](/assets/link-2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4.gif)
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Validation: In vivo validation
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Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPV4 |
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HCK | Co-immunoprecipitation | HEK293 | Mouse | Full-length | Not used | 12538589 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
![Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4](/assets/link-2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4.gif)
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Functional consequence
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TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | ||||||
TRPV4 |
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HCK | Calcium measurement | Activation | 12538589 | |||||||
TRPV4 |
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HCK | In vitro PTM assay | Phosphorylation (Tyr-273) | 12538589 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
![Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4](/assets/link-2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4.gif)