Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000250}.In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.

• GO:0070842 : aggresome assembly
• GO:0070301 : cellular response to hydrogen peroxide
• GO:0071218 : cellular response to misfolded protein
• GO:0035967 : cellular response to topologically incorrect protein
• GO:0016575 : histone deacetylation
• GO:0070846 : Hsp90 deacetylation
• GO:0006886 : intracellular protein transport
• GO:0032418 : lysosome localization
• GO:0016236 : macroautophagy
• GO:0006515 : misfolded or incompletely synthesized protein catabolic process
• GO:0010727 : negative regulation of hydrogen peroxide metabolic process
• GO:0007026 : negative regulation of microtubule depolymerization
• GO:0051354 : negative regulation of oxidoreductase activity
• GO:0043242 : negative regulation of protein complex disassembly
• GO:0045861 : negative regulation of proteolysis
• GO:0045892 : negative regulation of transcription, DNA-templated
• GO:0034983 : peptidyl-lysine deacetylation
• GO:0070845 : polyubiquitinated misfolded protein transport
• GO:0090035 : positive regulation of chaperone-mediated protein complex assembly
• GO:0010634 : positive regulation of epithelial cell migration
• GO:1901300 : positive regulation of hydrogen peroxide-mediated programmed cell death
• GO:0010870 : positive regulation of receptor biosynthetic process
• GO:0009967 : positive regulation of signal transduction
• GO:0043241 : protein complex disassembly
• GO:0006476 : protein deacetylation
• GO:0000209 : protein polyubiquitination
• GO:0060765 : regulation of androgen receptor signaling pathway
• GO:0070201 : regulation of establishment of protein localization
• GO:0060632 : regulation of microtubule-based movement
• GO:0010469 : regulation of receptor activity
• GO:0070848 : response to growth factor
• GO:0051788 : response to misfolded protein
• GO:0010033 : response to organic substance
• GO:0009636 : response to toxic substance
• GO:0006351 : transcription, DNA-templated
• GO:0090042 : tubulin deacetylation
• GO:0043162 : ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/