HSP90 / TRP channels
Name: Heat shock protein HSP 90-alpha
(HSP90)
Official Symbol: HSP90AA1
provided by HGNC
Function:
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
3320 |
P07900 |
DIP-27595N |
P07900 |
MINT-132070 |
109552 |
P07900 |
hsa:3320 |
140571 |
|
|
Mouse
|
15519 |
P07901 |
DIP-30975N |
P07901 |
MINT-152660 |
200455 |
P07901 |
mmu:15519 |
||
|
Rat
|
299331 |
P82995 |
DIP-37143N |
P82995 |
MINT-1775917 |
256205 |
P82995 |
rno:299331 |
||
PPI pairs:
Biological Process:
- GO:0007411
: axon guidance - GO:0051131 : chaperone-mediated protein complex assembly
- GO:0000086 : G2/M transition of mitotic cell cycle
- GO:0046209 : nitric oxide metabolic process
- GO:0045429 : positive regulation of nitric oxide biosynthetic process
- GO:0045040 : protein import into mitochondrial outer membrane
- GO:0042026 : protein refolding
- GO:0050999 : regulation of nitric-oxide synthase activity
- GO:0006986 : response to unfolded protein
- GO:0007165 : signal transduction
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPML1 |
|
HSP90 | Inference | Prediction | 19117012 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPML1 |
|
HSP90 | Co-immunoprecipitation | CHO | Human | Full-length | Not used | 19117012 | ||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)