ID2 / TRP channels

Name: DNA-binding protein inhibitor ID-2 (ID2)
Official Symbol: ID2 provided by HGNC
Function:
ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark c7dcdfe7852228a510704064c33a0706d8c0e915bceea718517e77f7950c2984
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f 		3398External Q02363External DIP-46874NExternal Q02363External MINT-1372728External 109624External Q02363External   hsa:3398External 600386External
Mouse
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f 		15902External P41136External DIP-167NExternal P41136External MINT-217665External 200506External P41136External   mmu:15902External  
Rat
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f 		25587External P41137External       247617External P41137External   rno:25587External  
PPI pairs:
Biological Process:
  • GO:0060612 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : adipose tissue development
  • GO:0003166 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : bundle of His development
  • GO:0048469 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : cell maturation
  • GO:0071285 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : cellular response to lithium ion
  • GO:0090398 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : cellular senescence
  • GO:0048557 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : embryonic digestive tract morphogenesis
  • GO:0061031 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : endodermal digestive tract morphogenesis
  • GO:0009649 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : entrainment of circadian clock
  • GO:0043353 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : enucleate erythrocyte differentiation
  • GO:0061030 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : epithelial cell differentiation involved in mammary gland alveolus development
  • GO:0033598 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : mammary gland epithelial cell proliferation
  • GO:0001656 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : metanephros development
  • GO:0001779 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : natural killer cell differentiation
  • GO:0045578 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : negative regulation of B cell differentiation
  • GO:0043392 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : negative regulation of DNA binding
  • GO:2000178 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : negative regulation of neural precursor cell proliferation
  • GO:0045665 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : negative regulation of neuron differentiation
  • GO:0048715 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : negative regulation of oligodendrocyte differentiation
  • GO:0045668 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : negative regulation of osteoblast differentiation
  • GO:0043433 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : negative regulation of sequence-specific DNA binding transcription factor activity
  • GO:0000122 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : negative regulation of transcription from RNA polymerase II promoter
  • GO:0045892 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : negative regulation of transcription, DNA-dependent
  • GO:0048663 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : neuron fate commitment
  • GO:0021772 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : olfactory bulb development
  • GO:0014003 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : oligodendrocyte development
  • GO:0048541 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : Peyer's patch development
  • GO:0048711 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : positive regulation of astrocyte differentiation
  • GO:0045777 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : positive regulation of blood pressure
  • GO:0045787 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : positive regulation of cell cycle
  • GO:0071158 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : positive regulation of cell cycle arrest
  • GO:0045648 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : positive regulation of erythrocyte differentiation
  • GO:0045600 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : positive regulation of fat cell differentiation
  • GO:0045651 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : positive regulation of macrophage differentiation
  • GO:0048661 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : positive regulation of smooth muscle cell proliferation
  • GO:0071931 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : positive regulation of transcription involved in G1/S phase of mitotic cell cycle
  • GO:2000045 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : regulation of G1/S transition of mitotic cell cycle
  • GO:0019216 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : regulation of lipid metabolic process
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Screening Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Functional consequence Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b top
Screening Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPP1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 ID2 Yeast two-hybrid Human 679-968 Human Fetal kidney cDNA library 16311606
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Screening Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Functional consequence Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b top
Validation: In vitro validation Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Assay with recombinant proteins Reference
TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Expression system Species Region Expression system
TRPP1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 ID2 Yeast two-hybrid Human 679-968 Yeast Human 1-134 Yeast 16311606
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Screening Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Functional consequence Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b top
Validation: In vivo validation Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPP1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 ID2 Co-immunofluorescence staining HEK293T Human Full-length Not used 16311606
TRPP1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 ID2 Co-immunoprecipitation HEK293T Human Full-length Not used 16311606
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Screening Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Functional consequence Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b top
Characterization Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPP1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 ID2 Yeast two-hybrid Human 679-968 Human 30-84 16311606
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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