IFT57 / TRP channels
Name: Intraflagellar transport protein 57 homolog
(IFT57)
Official Symbol: IFT57
provided by HGNC
Function:
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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55081![]() |
Q9NWB7![]() |
DIP-40434N![]() |
Q9NWB7![]() |
120396![]() |
Q9NWB7![]() |
hsa:55081![]() |
606621![]() |
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Mouse
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73916![]() |
Q8BXG3![]() |
216353![]() |
Q8BXG3![]() |
mmu:73916![]() |
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Rat
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303968![]() |
D4A1V1![]() |
257734![]() |
rno:303968![]() |
PPI pairs:
Biological Process:
- GO:0006919
: activation of cysteine-type endopeptidase activity involved in apoptotic process
- GO:0006355
: regulation of transcription, DNA-dependent
- GO:0006351
: transcription, DNA-dependent
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPP1 |
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IFT57 | Inference | Prediction | 15337773 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
![Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4](/assets/link-2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4.gif)
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Validation: In vivo validation
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Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPP1 |
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IFT57 | Co-immunoprecipitation | Tg737 Mouse 488 epithelial cell | 15337773 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
![Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4](/assets/link-2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4.gif)