KIF3B / TRP channels
Name: Kinesin-like protein KIF3B
(KIF3B)
Official Symbol: KIF3B
provided by HGNC
Function:
Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
![]() |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
![]() |
9371![]() |
O15066![]() |
DIP-42127N![]() |
O15066![]() |
MINT-1185610![]() |
114772![]() |
O15066![]() |
hsa:9371![]() |
603754![]() |
|
Mouse
![]() |
16569![]() |
Q61771![]() |
MINT-4597419![]() |
200942![]() |
Q61771![]() |
mmu:16569![]() |
||||
Rat
![]() |
296284![]() |
D3ZI07![]() |
255306![]() |
rno:296284![]() |
Biological Process:
- GO:0008089
: anterograde axon cargo transport
- GO:0019886
: antigen processing and presentation of exogenous peptide antigen via MHC class II
- GO:0007596
: blood coagulation
- GO:0007368
: determination of left/right symmetry
- GO:0007100
: mitotic centrosome separation
- GO:0072383
: plus-end-directed vesicle transport along microtubule
- GO:0090307
: spindle assembly involved in mitosis
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
![]() ![]() ![]() ![]() ![]() |
![]() |
Screening
![]() |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPP1 |
![]() |
KIF3B | Yeast two-hybrid | Human | 682-968 | Human | Heart | cDNA library | 16950792 | |
TRPP1 |
![]() |
KIF3B | Yeast two-hybrid | Human | 682-968 | Human | Heart | cDNA library | 17008358 | |
TRPV1 |
![]() |
KIF3B | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library | 17074976 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

![]() ![]() ![]() ![]() ![]() |
![]() |
Validation: In vitro validation
![]() |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Assay with recombinant proteins | Reference | |||||||||
TRP channel construct | Interactor construct | |||||||||
TRP channel | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system | ||
TRPP1 |
![]() |
KIF3B | Fusion protein-pull down assay | Human | 1-215 | E. coli | Not used | Mouse inner medullary collecting duct cell lysates | 17008358 | |
TRPP1 |
![]() |
KIF3B | Fusion protein-pull down assay | Human | 682-968 | E. coli | Not used | Mouse inner medullary collecting duct cell lysates | 17008358 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

![]() ![]() ![]() ![]() ![]() |
![]() |
Validation: In vivo validation
![]() |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPP1 |
![]() |
KIF3B | Co-immunofluorescence staining | Mouse inner medullary collecting duct cell | 17008358 | |||||
TRPP1 |
![]() |
KIF3B | Co-immunoprecipitation | MDCK | 17008358 | |||||
TRPP1 |
![]() |
KIF3B | Co-immunoprecipitation | Mouse inner medullary collecting duct cell | 17008358 | |||||
TRPP1 |
![]() |
KIF3B | Co-immunoprecipitation | Human kidney lysates | 17008358 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

![]() ![]() ![]() ![]() ![]() |
![]() |
Characterization
![]() |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | |||||||
TRP channel | Interactor | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPP1 |
![]() |
KIF3B | Fusion protein-pull down assay | Human | 682-968 | Human | 407-747 | 17008358 | ||
TRPP1 |
![]() |
KIF3B | Yeast two-hybrid | Human | 1-215 | Human | 407-747 | 17008358 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
