KRAS / TRP channels
Name: GTPase KRas
(KRAS)
Official Symbol: KRAS
provided by HGNC
Function:
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
3845 |
P01116 |
DIP-33951N |
P01116 |
MINT-131580 |
110043 |
P01116 |
hsa:3845 |
190070 |
|
|
Mouse
|
16653 |
P32883 |
DIP-29362N |
P32883 |
MINT-216577 |
201012 |
P32883 |
mmu:16653 |
||
|
Rat
|
24525 |
P08644 |
MINT-4586724 |
246680 |
P08644 |
rno:24525 |
||||
PPI pairs:
Biological Process:
- GO:0030036
: actin cytoskeleton organization - GO:0000186 : activation of MAPKK activity
- GO:0007411 : axon guidance
- GO:0007596 : blood coagulation
- GO:0019221 : cytokine-mediated signaling pathway
- GO:0007173 : epidermal growth factor receptor signaling pathway
- GO:0008543 : fibroblast growth factor receptor signaling pathway
- GO:0008286 : insulin receptor signaling pathway
- GO:0050900 : leukocyte migration
- GO:0000165 : MAPK cascade
- GO:0043524 : negative regulation of neuron apoptotic process
- GO:0048011 : nerve growth factor receptor signaling pathway
- GO:0008284 : positive regulation of cell proliferation
- GO:0010628 : positive regulation of gene expression
- GO:0043406 : positive regulation of MAP kinase activity
- GO:0051092 : positive regulation of NF-kappaB transcription factor activity
- GO:0051000 : positive regulation of nitric-oxide synthase activity
- GO:0035022 : positive regulation of Rac protein signal transduction
- GO:0007265 : Ras protein signal transduction
- GO:0048169 : regulation of long-term neuronal synaptic plasticity
- GO:0032228 : regulation of synaptic transmission, GABAergic
- GO:0051384 : response to glucocorticoid stimulus
- GO:0051385 : response to mineralocorticoid stimulus
- GO:0035176 : social behavior
- GO:0051146 : striated muscle cell differentiation
- GO:0008542 : visual learning
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:190070
:
Lung cancer
(OMIM:211980 )
- OMIM:190070
:
Bladder cancer
(OMIM:109800 )
- OMIM:190070
:
Breast cancer, somatic
(OMIM:114480 )
- OMIM:190070
:
Pancreatic carcinoma, somatic
(OMIM:260350 )
- OMIM:190070
:
Gastric cancer
(OMIM:137215 )
- OMIM:190070
:
Leukemia, acute myelogenous
(OMIM: )
- OMIM:190070
:
Noonan syndrome 3
(OMIM:609942 )
- OMIM:190070
:
Cardiofaciocutaneous syndrome
(OMIM:115150 )
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
Screening
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|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPP1 |
|
KRAS | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)