Myosin-10 / TRP channels
Name: Myosin-10
(Myosin-10)
Official Symbol: MYH10
provided by HGNC
Function:
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
4628 |
P35580 |
DIP-31110N |
P35580 |
MINT-1133516 |
110713 |
P35580 |
hsa:4628 |
160776 |
|
|
Mouse
|
77579 |
Q61879 |
DIP-31956N |
Q61879 |
MINT-4102674 |
218774 |
Q61879 |
mmu:77579 |
||
|
Rat
|
79433 |
Q9JLT0 |
MINT-4568339 |
249464 |
Q9JLT0 |
rno:79433 |
||||
Biological Process:
- GO:0030048
: actin filament-based movement - GO:0007512 : adult heart development
- GO:0007411 : axon guidance
- GO:0055003 : cardiac myofibril assembly
- GO:0008283 : cell proliferation
- GO:0021680 : cerebellar Purkinje cell layer development
- GO:0000281 : cytokinesis after mitosis
- GO:0006887 : exocytosis
- GO:0021592 : fourth ventricle development
- GO:0001701 : in utero embryonic development
- GO:0021670 : lateral ventricle development
- GO:0050885 : neuromuscular process controlling balance
- GO:0001764 : neuron migration
- GO:0007097 : nuclear migration
- GO:0001778 : plasma membrane repair
- GO:0008360 : regulation of cell shape
- GO:0060041 : retina development in camera-type eye
- GO:0006930 : substrate-dependent cell migration, cell extension
- GO:0021678 : third ventricle development
- GO:0055015 : ventricular cardiac muscle cell development
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPC3 |
|
Myosin-10 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC5 |
|
Myosin-10 | Affinity purification-mass spectrometry | Endogenous protein | Rat | Brain | Cerebral cortex lysates | 16025302 | ||
| TRPV4 |
|
Myosin-10 | Affinity purification-mass spectrometry | Mouse | Full-length | Human | HEK293 | Cell lystaes | 22492541 | |
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPV4 |
|
Myosin-10 | Co-immunofluorescence staining | HEK293 | Mouse | Full-length | Not used | 22492541 | ||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)