Myosin-5a / TRP channels
Name: Unconventional myosin-Va
(Myosin-5a)
Official Symbol: MYO5A
provided by HGNC
Function:
Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
4644 |
Q9Y4I1 |
DIP-44243N |
Q9Y4I1 |
MINT-3388025 |
110728 |
Q9Y4I1 |
hsa:4644 |
160777 |
|
|
Mouse
|
17918 |
Q99104 |
DIP-29542N |
Q99104 |
MINT-243234 |
201666 |
Q99104 |
mmu:17918 |
||
|
Rat
|
25017 |
Q9QYF3 |
DIP-57326N |
MINT-7138773 |
247098 |
Q9QYF3 |
rno:25017 |
|||
PPI pairs:
Biological Process:
- GO:0030048
: actin filament-based movement - GO:0042640 : anagen
- GO:0032869 : cellular response to insulin stimulus
- GO:0051643 : endoplasmic reticulum localization
- GO:0006887 : exocytosis
- GO:0030073 : insulin secretion
- GO:0031987 : locomotion involved in locomotory behavior
- GO:0042759 : long-chain fatty acid biosynthetic process
- GO:0042438 : melanin biosynthetic process
- GO:0030318 : melanocyte differentiation
- GO:0032402 : melanosome transport
- GO:0042552 : myelination
- GO:0042476 : odontogenesis
- GO:0072659 : protein localization to plasma membrane
- GO:0031585 : regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
- GO:0032252 : secretory granule localization
- GO:0050808 : synapse organization
- GO:0007268 : synaptic transmission
- GO:0016192 : vesicle-mediated transport
- GO:0007601 : visual perception
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:160777
:
Griscelli syndrome, type 1
(OMIM:214450 )
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
Screening
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPC5 |
|
Myosin-5a | Affinity purification-mass spectrometry | Endogenous protein | Rat | Brain | Cerebral cortex lysates | 16025302 | ||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)