Myosin-HIIA / TRP channels
Name: Myosin-9
(Myosin-HIIA)
Official Symbol: MYH9
provided by HGNC
Function:
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
4627 |
P35579 |
DIP-33103N |
P35579 |
MINT-1147379 |
110712 |
P35579 |
hsa:4627 |
160775 |
|
|
Mouse
|
17886 |
Q8VDD5 |
DIP-29546N |
Q8VDD5 |
MINT-2524850 |
201650 |
Q8VDD5 |
mmu:17886 |
||
|
Rat
|
25745 |
Q62812 |
DIP-43726N |
Q62812 |
MINT-2778870 |
247773 |
Q62812 |
rno:25745 |
||
Biological Process:
- GO:0031532
: actin cytoskeleton reorganization - GO:0030048 : actin filament-based movement
- GO:0001525 : angiogenesis
- GO:0007411 : axon guidance
- GO:0043534 : blood vessel endothelial cell migration
- GO:0016337 : cell-cell adhesion
- GO:0000910 : cytokinesis
- GO:0051295 : establishment of meiotic spindle localization
- GO:0001768 : establishment of T cell polarity
- GO:0001701 : in utero embryonic development
- GO:0007229 : integrin-mediated signaling pathway
- GO:0050900 : leukocyte migration
- GO:0007132 : meiotic metaphase I
- GO:0000212 : meiotic spindle organization
- GO:0006509 : membrane protein ectodomain proteolysis
- GO:0030224 : monocyte differentiation
- GO:0007520 : myoblast fusion
- GO:0030220 : platelet formation
- GO:0015031 : protein transport
- GO:0008360 : regulation of cell shape
- GO:0038032 : termination of G-protein coupled receptor signaling pathway
- GO:0032796 : uropod organization
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:160775
:
May-Hegglin anomaly
(OMIM:155100 )
- OMIM:160775
:
Fechtner syndrome
(OMIM:153640 )
- OMIM:160775
:
Sebastian syndrome
(OMIM:605249 )
- OMIM:160775
:
Deafness, autosomal dominant 17
(OMIM:603622 )
- OMIM:160775
:
Epstein syndrome
(OMIM:153650 )
- OMIM:160775
:
Macrothrombocytopenia and progressive sensorineural deafness
(OMIM:600208 )
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPC5 |
|
Myosin-HIIA | Affinity purification-mass spectrometry | Endogenous protein | Rat | Brain | Cerebral cortex lysates | 16025302 | ||
| TRPM7 |
|
Myosin-HIIA | Inference | Prediction | 16407977 | |||||
| TRPV4 |
|
Myosin-HIIA | Affinity purification-mass spectrometry | Mouse | Full-length | Human | HEK293 | Cell lystaes | 22492541 | |
(:
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:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPM7 |
|
Myosin-HIIA | Co-immunoprecipitation | N1E-115 neuroblastoma cell | Mouse | Full-length | Not used | 16407977 | ||
| TRPM7 |
|
Myosin-HIIA | Co-immunoprecipitation | PC12 | 16407977 | |||||
| TRPV4 |
|
Myosin-HIIA | Co-immunofluorescence staining | HEK293 | Mouse | Full-length | Not used | 22492541 | ||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Characterization
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | |||||||
| TRP channel | Interactor | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPM7 |
|
Myosin-HIIA | Co-immunoprecipitation | Mouse | 1158-1864 | Mouse | 1795-1960 | 16407977 | ||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)