NEK8 / TRP channels
Name: Serine/threonine-protein kinase Nek8
(NEK8)
Official Symbol: NEK8
provided by HGNC
Function:
Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
284086 |
Q86SG6 |
DIP-52329N |
Q86SG6 |
UNK-5850088 |
129755 |
Q86SG6 |
hsa:284086 |
609799 |
|
|
Mouse
|
140859 |
Q91ZR4 |
DIP-42243N |
Q91ZR4 |
MINT-1341145 |
228327 |
Q91ZR4 |
mmu:140859 |
||
|
Rat
|
287473 |
D3ZGQ5 |
252185 |
rno:287473 |
||||||
PPI pairs:
Biological Process:
No information in Gene Ontology
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:609799
:
Nephronophthisis 9
(OMIM:613824 )
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPP1 |
|
NEK8 | Inference | Prediction | 18235101 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPP1 |
|
NEK8 | Co-immunofluorescence staining | Mouse kidney section | 18235101 | |||||
| TRPP1 |
|
NEK8 | Co-immunoprecipitation | Mouse kidney tissue | 18235101 | |||||
| TRPP1 |
|
NEK8 | Co-immunoprecipitation | Mouse Inner medullary collecting duct cell | 18235101 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)