NKX2.2 / TRP channels
Name: Homeobox protein Nkx-2.2
(NKX2.2)
Official Symbol: NKX2-2
provided by HGNC
Function:
Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
4821 |
O95096 |
DIP-58072N |
UNK-5367814 |
110886 |
O95096 |
hsa:4821 |
604612 |
||
|
Mouse
|
18088 |
P42586 |
MINT-4103861 |
201776 |
P42586 |
mmu:18088 |
||||
|
Rat
|
366214 |
D3ZDQ2 |
265801 |
rno:366214 |
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PPI pairs:
Biological Process:
- GO:0048708
: astrocyte differentiation - GO:0007420 : brain development
- GO:0048565 : digestive tract development
- GO:0031018 : endocrine pancreas development
- GO:0045665 : negative regulation of neuron differentiation
- GO:0048665 : neuron fate specification
- GO:0014003 : oligodendrocyte development
- GO:0003326 : pancreatic A cell fate commitment
- GO:0003329 : pancreatic PP cell fate commitment
- GO:0045666 : positive regulation of neuron differentiation
- GO:0048714 : positive regulation of oligodendrocyte differentiation
- GO:0051091 : positive regulation of sequence-specific DNA binding transcription factor activity
- GO:0045944 : positive regulation of transcription from RNA polymerase II promoter
- GO:0007224 : smoothened signaling pathway
- GO:0021522 : spinal cord motor neuron differentiation
- GO:0021530 : spinal cord oligodendrocyte cell fate specification
- GO:0006351 : transcription, DNA-dependent
- GO:0003323 : type B pancreatic cell development
- GO:0003327 : type B pancreatic cell fate commitment
- GO:0060580 : ventral spinal cord interneuron fate determination
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPV1 |
|
NKX2.2 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library | 17074976 | |
(:
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:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)