NMDAR1 / TRP channels
Name: Glutamate receptor ionotropic, NMDA 1
(NMDAR1)
Official Symbol: GRIN1
provided by HGNC
Function:
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
2902 |
Q05586 |
DIP-36736N |
Q05586 |
MINT-1900224 |
109159 |
Q05586 |
hsa:2902 |
138249 |
|
|
Mouse
|
14810 |
P35438 |
DIP-31577N |
P35438 |
MINT-135802 |
200067 |
P35438 |
mmu:14810 |
||
|
Rat
|
24408 |
P35439 |
DIP-674N |
P35439 |
MINT-101336 |
246573 |
P35439 |
rno:24408 |
||
PPI pairs:
Biological Process:
- GO:0055074
: calcium ion homeostasis - GO:0070588 : calcium ion transmembrane transport
- GO:0035235 : ionotropic glutamate receptor signaling pathway
- GO:2000463 : positive regulation of excitatory postsynaptic membrane potential
- GO:0045944 : positive regulation of transcription from RNA polymerase II promoter
- GO:0018964 : propylene metabolic process
- GO:0045471 : response to ethanol
- GO:0008542 : visual learning
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:138249
:
Mental retardation, autosomal dominant 8
(OMIM:614254 )
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPV1 |
|
NMDAR1 | Inference | Prediction | 22609428 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPV1 |
|
NMDAR1 | Co-immunofluorescence staining | Rat trigeminal ganglia lysates | 22609428 | |||||
| TRPV1 |
|
NMDAR1 | Co-immunoprecipitation | Rat trigeminal ganglia lysates | 22609428 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)