NMDAR2B / TRP channels
Name: Glutamate receptor ionotropic, NMDA 2B
(NMDAR2B)
Official Symbol: GRIN2B
provided by HGNC
Function:
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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2904![]() |
Q13224![]() |
DIP-41002N![]() |
Q13224![]() |
MINT-127466![]() |
109161![]() |
Q13224![]() |
hsa:2904![]() |
138252![]() |
|
Mouse
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14812![]() |
Q01097![]() |
DIP-31568N![]() |
Q01097![]() |
MINT-135847![]() |
200069![]() |
Q01097![]() |
mmu:14812![]() |
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Rat
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24410![]() |
Q00960![]() |
DIP-33702N![]() |
Q00960![]() |
MINT-104014![]() |
246575![]() |
Q00960![]() |
rno:24410![]() |
PPI pairs:
Biological Process:
- GO:0008306
: associative learning
- GO:0001662
: behavioral fear response
- GO:0048266
: behavioral response to pain
- GO:0071230
: cellular response to amino acid stimulus
- GO:0071359
: cellular response to dsRNA
- GO:0071363
: cellular response to growth factor stimulus
- GO:0071396
: cellular response to lipid
- GO:0010350
: cellular response to magnesium starvation
- GO:0071287
: cellular response to manganese ion
- GO:0021987
: cerebral cortex development
- GO:0050966
: detection of mechanical stimulus involved in sensory perception of pain
- GO:0021766
: hippocampus development
- GO:0001701
: in utero embryonic development
- GO:0007611
: learning or memory
- GO:0007616
: long-term memory
- GO:0010942
: positive regulation of cell death
- GO:0014049
: positive regulation of glutamate secretion
- GO:0050806
: positive regulation of synaptic transmission
- GO:0043113
: receptor clustering
- GO:0001508
: regulation of action potential
- GO:0060079
: regulation of excitatory postsynaptic membrane potential
- GO:0048169
: regulation of long-term neuronal synaptic plasticity
- GO:0043408
: regulation of MAPK cascade
- GO:0001975
: response to amphetamine
- GO:0051592
: response to calcium ion
- GO:0009743
: response to carbohydrate stimulus
- GO:0042220
: response to cocaine
- GO:0034097
: response to cytokine stimulus
- GO:0051602
: response to electrical stimulus
- GO:0045471
: response to ethanol
- GO:0060992
: response to fungicide
- GO:0060416
: response to growth hormone stimulus
- GO:0032026
: response to magnesium ion
- GO:0051597
: response to methylmercury
- GO:0051707
: response to other organism
- GO:0048511
: rhythmic process
- GO:0007423
: sensory organ development
- GO:0001964
: startle response
- GO:0001967
: suckling behavior
- GO:0007268
: synaptic transmission
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:138252
: Mental retardation, autosomal dominant 6 (OMIM:613970
)
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPV1 |
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NMDAR2B | Inference | Prediction | 22609428 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vivo validation
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Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPV1 |
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NMDAR2B | Co-immunoprecipitation | Rat trigeminal ganglia lysates | 22609428 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
