Neurofascin / TRP channels
Name: Neurofascin
(Neurofascin)
Official Symbol: NFASC
provided by HGNC
Function:
Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species | External DB | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
23114 | O94856 | O94856 | MINT-2798373 | 116737 | O94856 | hsa:23114 | 609145 | ||
Mouse
|
269116 | Q810U3 | Q810U3 | 234609 | Q810U3 | mmu:269116 | ||||
Rat
|
116690 | P97685 | 250572 | P97685 | rno:116690 |
PPI pairs:
Biological Process:
- GO:0007411 : axon guidance
- GO:0007155 : cell adhesion
- GO:0042552 : myelination
- GO:0030913 : paranodal junction assembly
- GO:0007422 : peripheral nervous system development
- GO:0071205 : protein localization to juxtaparanode region of axon
- GO:0002175 : protein localization to paranode region of axon
- GO:0050808 : synapse organization
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top |
Screening | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPC3 | Neurofascin | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 |
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)