Nyctalopin / TRP channels
Name: Nyctalopin
(Nyctalopin)
Official Symbol: NYX
provided by HGNC
Function:
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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60506![]() |
Q9GZU5![]() |
121934![]() |
Q9GZU5![]() |
hsa:60506![]() |
300278![]() |
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Mouse
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236690![]() |
P83503![]() |
231783![]() |
P83503![]() |
mmu:236690![]() |
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Rat
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302516![]() |
A1XIQ3![]() |
257217![]() |
A1XIQ3![]() |
rno:302516![]() |
PPI pairs:
Biological Process:
- GO:0050896
: response to stimulus
- GO:0007601
: visual perception
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:300278
: Night blindness, congenital stationary, type 1A (OMIM:310500
)
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPM1 |
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Nyctalopin | Inference | Prediction | 21734298 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
![Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4](/assets/link-2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4.gif)
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Validation: In vitro validation
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Assay with recombinant proteins | Reference | |||||||||
TRP channel construct | Interactor construct | |||||||||
TRP channel | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system | ||
TRPM1 |
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Nyctalopin | Yeast two-hybrid | Mouse | Full-length | Yeast | Mouse | Full-length | Yeast | 21734298 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
![Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4](/assets/link-2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4.gif)
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Validation: In vivo validation
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Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPM1 |
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Nyctalopin | Co-immunofluorescence staining | Mouse retinal section | Mouse | Full-length | Mouse | Full-length | 21734298 | |
TRPM1 |
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Nyctalopin | Co-immunoprecipitation | HEK293T | Mouse | Full-length | Mouse | Full-length | 21734298 | |
TRPM1 |
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Nyctalopin | Co-immunoprecipitation | HEK293T | Mouse | Full-length | Mouse | Full-length | 21832182 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
![Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4](/assets/link-2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4.gif)
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Functional consequence
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TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | ||||||
TRPM1 |
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Nyctalopin | Patch clamp | Activation | 21734298 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
![Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4](/assets/link-2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4.gif)