PMCA2 / TRP channels
Name: Plasma membrane calcium-transporting ATPase 2
(PMCA2)
Official Symbol: ATP2B2
provided by HGNC
Function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
491 |
Q01814 |
Q01814 |
MINT-470839 |
106981 |
Q01814 |
hsa:491 |
108733 |
||
|
Mouse
|
11941 |
Q9R0K7 |
Q9R0K7 |
198250 |
Q9R0K7 |
mmu:11941 |
||||
|
Rat
|
24215 |
P11506 |
P11506 |
MINT-471009 |
246403 |
P11506 |
rno:24215 |
|||
PPI pairs:
Biological Process:
- GO:0006754
: ATP biosynthetic process - GO:0060088 : auditory receptor cell stereocilium organization
- GO:0007596 : blood coagulation
- GO:0021707 : cerebellar granule cell differentiation
- GO:0021702 : cerebellar Purkinje cell differentiation
- GO:0046068 : cGMP metabolic process
- GO:0090102 : cochlea development
- GO:0051480 : cytosolic calcium ion homeostasis
- GO:0050910 : detection of mechanical stimulus involved in sensory perception of sound
- GO:0007595 : lactation
- GO:0040011 : locomotion
- GO:0007626 : locomotory behavior
- GO:0003407 : neural retina development
- GO:0050885 : neuromuscular process controlling balance
- GO:0030182 : neuron differentiation
- GO:0006996 : organelle organization
- GO:0045299 : otolith mineralization
- GO:0051928 : positive regulation of calcium ion transport
- GO:0008361 : regulation of cell size
- GO:0048167 : regulation of synaptic plasticity
- GO:0007605 : sensory perception of sound
- GO:0042428 : serotonin metabolic process
- GO:0050808 : synapse organization
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:108733
:
Deafness, autosomal recessive 12, modifier of
(OMIM:601386 )
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
|
Screening
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|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPC3 |
|
PMCA2 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)