PSMD7 / TRP channels

Name: 26S proteasome non-ATPase regulatory subunit 7 (PSMD7)
Official Symbol: PSMD7 provided by HGNC
Function:
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark c7dcdfe7852228a510704064c33a0706d8c0e915bceea718517e77f7950c2984
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f 		5713External P51665External DIP-27572NExternal P51665External MINT-5002613External 111685External P51665External   hsa:5713External 157970External
Mouse
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f 		17463External P26516External DIP-35175NExternal P26516External MINT-4108972External 201472External P26516External   mmu:17463External  
Rat
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f 		307821External D4AEH3External DIP-56041NExternal D4AEH3External   258820External     rno:307821External  
PPI pairs:
Biological Process:
  • GO:0031145 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • GO:0002479 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
  • GO:0006915 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : apoptotic process
  • GO:0006977 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
  • GO:0000082 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : G1/S transition of mitotic cell cycle
  • GO:0010467 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : gene expression
  • GO:0000216 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : M/G1 transition of mitotic cell cycle
  • GO:0016071 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : mRNA metabolic process
  • GO:0051436 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  • GO:0051437 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  • GO:0000209 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : protein polyubiquitination
  • GO:0042981 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : regulation of apoptotic process
  • GO:0006521 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : regulation of cellular amino acid metabolic process
  • GO:0000084 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : S phase of mitotic cell cycle
  • GO:0044281 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : small molecule metabolic process
  • GO:0016032 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : viral reproduction
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Screening Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Functional consequence Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b top
Screening Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPP1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PSMD7 Inference Prediction 18178578
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Screening Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Functional consequence Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b top
Validation: In vivo validation Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPP1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PSMD7 Co-immunoprecipitation Mouse Inner medullary collecting duct cell 18178578
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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