Pericentrin / TRP channels
Name: Pericentrin
(Pericentrin)
Official Symbol: PCNT
provided by HGNC
Function:
Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
5116 |
O95613 |
DIP-33829N |
O95613 |
MINT-4527763 |
111146 |
O95613 |
hsa:5116 |
605925 |
|
|
Mouse
|
18541 |
P48725 |
DIP-54639N |
P48725 |
MINT-4084690 |
202052 |
P48725 |
mmu:18541 |
||
| Rat | ||||||||||
PPI pairs:
Biological Process:
- GO:0006915
: apoptotic process - GO:0048854 : brain morphogenesis
- GO:0021696 : cerebellar cortex morphogenesis
- GO:0042384 : cilium assembly
- GO:0000086 : G2/M transition of mitotic cell cycle
- GO:0001701 : in utero embryonic development
- GO:0035108 : limb morphogenesis
- GO:0000226 : microtubule cytoskeleton organization
- GO:0035264 : multicellular organism growth
- GO:0061351 : neural precursor cell proliferation
- GO:0001764 : neuron migration
- GO:0021772 : olfactory bulb development
- GO:0007051 : spindle organization
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:605925
:
Microcephalic osteodysplastic primordial dwarfism, type II
(OMIM:210720 )
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPP1 |
|
Pericentrin | Inference | Prediction | 15337773 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPP1 |
|
Pericentrin | Co-immunofluorescence staining | RPE1 | 15337773 | |||||
| TRPP1 |
|
Pericentrin | Co-immunoprecipitation | RPE1 | 15337773 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)