RAB21 / TRP channels
Name: Ras-related protein Rab-21
(RAB21)
Official Symbol: RAB21
provided by HGNC
Function:
Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
![]() |
23011![]() |
Q9UL25![]() |
DIP-29349N![]() |
Q9UL25![]() |
MINT-3081967![]() |
116653![]() |
Q9UL25![]() |
hsa:23011![]() |
612398![]() |
|
Mouse
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216344![]() |
P35282![]() |
DIP-46948N![]() |
P35282![]() |
MINT-1863390![]() |
229733![]() |
P35282![]() |
mmu:216344![]() |
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Rat
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299799![]() |
Q6AXT5![]() |
UNK-5470897![]() |
256334![]() |
Q6AXT5![]() |
rno:299799![]() |
PPI pairs:
Biological Process:
- GO:0015031
: protein transport
- GO:0007264
: small GTPase mediated signal transduction
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPP1 |
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RAB21 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
