RP2 / TRP channels
Name: Protein XRP2
(RP2)
Official Symbol: RP2
provided by HGNC
Function:
Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
6102 |
O75695 |
DIP-29024N |
MINT-5003911 |
112029 |
O75695 |
hsa:6102 |
300757 |
||
|
Mouse
|
19889 |
Q9EPK2 |
DIP-32103N |
Q9EPK2 |
UNK-5545197 |
202960 |
Q9EPK2 |
mmu:19889 |
||
|
Rat
|
367714 |
D3ZX47 |
266619 |
rno:367714 |
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PPI pairs:
Biological Process:
- GO:0000902
: cell morphogenesis - GO:0006241 : CTP biosynthetic process
- GO:0006183 : GTP biosynthetic process
- GO:0006457 : protein folding
- GO:0015031 : protein transport
- GO:0006228 : UTP biosynthetic process
- GO:0007601 : visual perception
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:300757
:
Retinitis pigmentosa 2
(OMIM:312600 )
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPP1 |
|
RP2 | Inference | Prediction | 20729296 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPP1 |
|
RP2 | Co-immunoprecipitation | Bovine retinal extract | 20729296 | |||||
| TRPP1 |
|
RP2 | Co-immunoprecipitation | MDCK | Not used | Human | Full-length | 20729296 | ||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)