Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells. Enhances phosphorylation of HIV-1 Nef by PKCs. Promotes migration of breast carcinoma cells by binding to and activating RHOA.

• GO:0007049 : cell cycle
• GO:0007369 : gastrulation
• GO:0030308 : negative regulation of cell growth
• GO:0050765 : negative regulation of phagocytosis
• GO:0051898 : negative regulation of protein kinase B signaling cascade
• GO:0017148 : negative regulation of translation
• GO:0030178 : negative regulation of Wnt receptor signaling pathway
• GO:0043065 : positive regulation of apoptotic process
• GO:0030335 : positive regulation of cell migration
• GO:2000543 : positive regulation of gastrulation
• GO:0043547 : positive regulation of GTPase activity
• GO:2001244 : positive regulation of intrinsic apoptotic signaling pathway
• GO:0032436 : positive regulation of proteasomal ubiquitin-dependent protein catabolic process
• GO:0032464 : positive regulation of protein homooligomerization
• GO:0001934 : positive regulation of protein phosphorylation
• GO:0051726 : regulation of cell cycle
• GO:0051302 : regulation of cell division
• GO:2000114 : regulation of establishment of cell polarity
• GO:0032880 : regulation of protein localization
• GO:0048511 : rhythmic process
• GO:0019048 : virus-host interaction

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/